The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.217422
Abstract: ABSTRACT Neutrophils sense and respond to diverse chemotactic cues through G-protein-coupled receptors (GPCRs). However, the precise trafficking dynamics of chemoattractant GPCRs during neutrophil activation and chemotaxis remain unclear. Here, by using small-molecule inhibitors and CRISPR-based… read more here.
Keywords: chemoattractant gpcrs; blt1; polarized trafficking; chemotaxis ... See more keywords
Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking
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DOI: 10.7554/elife.69229
Abstract: Migrating cells present a variety of paths, from random to highly directional ones. While random movement can be explained by basal intrinsic activity, persistent movement requires stable polarization. Here, we quantitatively address emergence of persistent… read more here.
Keywords: cell; polarized trafficking; migration; migration emerges ... See more keywords