Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52414-z
Abstract: POLE/POLD1 gene variants have been suggested as potential markers for immunotherapy due to their significant association with the tumor mutational burden (TMB), an effective indicator for response prediction in immunotherapy. However, the correlation of POLE/POLD1… read more here.
Keywords: pold1; pold1 gene; cancer patients; pole pold1 ... See more keywords
Unraveling the impact of a germline heterozygous POLD1 frameshift variant in serrated polyposis syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1119900
Abstract: Serrated polyposis syndrome (SPS) is one of the most frequent polyposis syndromes characterized by an increased risk for developing colorectal cancer (CRC). Although SPS etiology has been mainly associated with environmental factors, germline predisposition to… read more here.
Keywords: frameshift; pold1; serrated polyposis; frameshift variant ... See more keywords
Elevated expression of POLD1 is associated with poor prognosis in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.9392
Abstract: Polymerase δ catalytic subunit gene 1 (POLD1) may serve an important function in the development of tumors. However, its role in breast cancer remains unclear. The aim of the present study was to observe the… read more here.
Keywords: pold1; expression pold1; expression; breast cancer ... See more keywords