Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.203703
Abstract: ABSTRACT Nonsense mutations in the ASPM gene have been most frequently identified among familial microcephaly patients. Depletion of the Drosophila orthologue (asp) causes spindle pole unfocusing during mitosis in multiple cell types. However, it remains… read more here.
Keywords: protein; pole focusing; microcephaly; spindle pole ... See more keywords
CEP215 and AURKA regulate spindle pole focusing and aMTOC organization in mouse oocytes.
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DOI: 10.1530/rep-19-0263
Abstract: Acentriolar microtubule-organizing centers (aMTOCs) play a critical role in stable meiotic spindle assembly in oocytes, necessary for accurate chromosome segregation. Yet, there is a limited understanding of the essential regulatory components of these unique MTOCs.… read more here.
Keywords: organization; mouse oocytes; amtoc organization; pole focusing ... See more keywords