Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization
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DOI: 10.1016/j.celrep.2020.107757
Abstract: Summary The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif. Here we show that… read more here.
Keywords: rich motifs; localization; proline rich; phosphorylation ... See more keywords
Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
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DOI: 10.1038/s41467-017-01876-8
Abstract: The Polo kinase is a master regulator of mitosis and cytokinesis conserved from yeasts to humans. Polo is composed of an N-term kinase domain (KD) and a C-term polo-box domain (PBD), which regulates its subcellular… read more here.
Keywords: kinase; activation; entry; mitotic entry ... See more keywords