Synergism and antagonism in mixed monolayers: Brij S20/poloxamer 407 and Triton X-100/poloxamer 407 mixtures
Sign Up to like & getrecommendations! Published in 2018 at "Fluid Phase Equilibria"
DOI: 10.1016/j.fluid.2018.06.009
Abstract: Abstract Knowledge of nonideal behavior of surfactant mixtures of nonionic surfactants at air/aqueous solution interface is important in order to obtain surfactant mixtures with improved properties. In this work interfacial behavior of Brij S20/P407 and… read more here.
Keywords: triton 100; mixed monolayers; brij s20; s20 poloxamer ... See more keywords
Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.03.010
Abstract: Surfactants play an important role in stabilizing proteins in liquid formulations against aggregate/particle formation during processing, handling, storage, and transportation. Only three surfactants are currently used in marketed therapeutic protein formulations: polysorbate 20, polysorbate 80,… read more here.
Keywords: antibody formulations; poloxamer; protein polydimethylsiloxane; poloxamer 188 ... See more keywords
Optimization of thermoreversible poloxamer gel system using QbD principle
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2016.1219371
Abstract: Abstract The objective of this study was to optimize thermoreversible gel formulations with respect to their gelation temperature and solubilizing capacity, using quality by design (QbD) principles based on design of experiment (DoE). Independent variables,… read more here.
Keywords: gelation; gelation temperature; poloxamer; gel ... See more keywords
Mode of action of poloxamer‐based surfactants in wound care and efficacy on biofilms
Sign Up to like & getrecommendations! Published in 2018 at "International Wound Journal"
DOI: 10.1111/iwj.12922
Abstract: Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispersants in both the food and oil industry. Their use in a clinical setting is also common, particularly in wound care. Complicated or… read more here.
Keywords: poloxamer based; wound care; poloxamer; surfactants wound ... See more keywords
Dual Asymmetric Centrifugation Efficiently Produces a Poloxamer-Based Nanoemulsion Gel for Topical Delivery of Pirfenidone
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01798-7
Abstract: This study used dual asymmetric centrifugation (DAC) to produce a topical vehicle for Pirfenidone (Pf; 5-methyl-1-phenyl-2[1H]-pyridone)—a Food and Drug Administration-approved antifibrotic drug indicated for idiopathic fibrosis treatment. Pf was loaded (8 wt%) in a poloxamer… read more here.
Keywords: nanoemulsion gel; poloxamer; asymmetric centrifugation; pirfenidone ... See more keywords
Smart thermosensitive poloxamer hydrogels loaded with Nr-CWs for the treatment of diabetic wounds
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279727
Abstract: The treatment of diabetic wound is a focus issue. At present, the Nocardia rubra cell wall skeleton (Nr-CWS) has been proved proven to promote angiogenesis and wound repair. Unfortunately, the high-glucose diabetic wound environment makes… read more here.
Keywords: thermosensitive poloxamer; loaded cws; poloxamer; smart thermosensitive ... See more keywords
Effect of the Surfactant Charge on the Characteristics and Anticancer Effects of Docetaxel-loaded Poloxamer Polymeric Micelles.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738511666221103152156
Abstract: BACKGROUND The main problem in the use of docetaxel as a potent chemotherapeutic agent is its solubility. Practically insoluble docetaxel requires a harsh formulation with high surfactant and alcohol concentrations to comply with the product… read more here.
Keywords: effect; loaded poloxamer; poloxamer; polymeric micelles ... See more keywords
pH-Responsive Hydrogel Beads Based on Alginate, κ-Carrageenan and Poloxamer for Enhanced Curcumin, Natural Bioactive Compound, Encapsulation and Controlled Release Efficiency
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134045
Abstract: Polyphenolic compounds are used for treating various diseases due to their antioxidant and anticancer properties. However, utilization of hydrophobic compounds is limited due to their low bioavailability. In order to achieve a greater application of… read more here.
Keywords: hydrogel beads; curcumin; poloxamer; encapsulation ... See more keywords
Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics10030156
Abstract: Aqueous-based nail lacquers have shown potential in promoting the diffusion of drugs into the nail. In our laboratory, we have recently developed a transungual delivery system based on an aqueous dispersion of cyclodextrin-poloxamer soluble polypseudorotaxanes,… read more here.
Keywords: lacquer; cyclodextrin; nail; poloxamer ... See more keywords
Evaluation of Ribavirin–Poloxamer Microparticles for Improved Intranasal Absorption
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13081126
Abstract: Ribavirin is a water-soluble antiviral compound which, owing to its inability to cross the blood–brain barrier, has limited effectiveness in treating viruses affecting the central nervous system. Direct nose-to-brain delivery was investigated for ribavirin in… read more here.
Keywords: absorption; poloxamer microparticles; poloxamer; ribavirin poloxamer ... See more keywords