Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.03.049
Abstract: The paramount problem in the therapy of brain tumors is the inability of most drugs to cross the blood-brain barrier. PLGA nanoparticles overcoated with poloxamer 188 could overcome this problem and enabled a high anti-tumoral… read more here.
Keywords: glioblastoma; plga nanoparticles; brain; doxorubicin ... See more keywords
Simultaneous quantification of polysorbate 20 and poloxamer 188 in biopharmaceutical formulations using evaporative light scattering detection.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113640
Abstract: Polysorbates and Poloxamer 188 constitute the most common surfactants used in biopharmaceutical formulations owing to their excellent protein-stabilizing properties and good safety profiles. In recent years, however, a vast number of reports concerning potential risk… read more here.
Keywords: scattering detection; biopharmaceutical formulations; polysorbate poloxamer; evaporative light ... See more keywords
Solution Stability of Poloxamer 188 Under Stress Conditions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.057
Abstract: Poloxamer 188 (P188) is a triblock copolymer of the form polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO). The center PPO block is hydrophobic, and the side PEO blocks are hydrophilic, resulting in surface-active properties. P188 has been… read more here.
Keywords: degradation; p188; solution stability; poloxamer 188 ... See more keywords
Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.03.010
Abstract: Surfactants play an important role in stabilizing proteins in liquid formulations against aggregate/particle formation during processing, handling, storage, and transportation. Only three surfactants are currently used in marketed therapeutic protein formulations: polysorbate 20, polysorbate 80,… read more here.
Keywords: antibody formulations; poloxamer; protein polydimethylsiloxane; poloxamer 188 ... See more keywords
Impact of Poloxamer 188 Material Attributes on Proteinaceous Visible Particle Formation in Liquid Monoclonal Antibody Formulations.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.04.012
Abstract: Surfactants such as Poloxamer 188 (PX188) play an important role in controlling particle formation in biotherapeutic formulations due to interfacial stresses. This study demonstrates for the first time that hydrophobicity of PX188 is a potential… read more here.
Keywords: particle formation; material attributes; poloxamer 188; formation ... See more keywords
Pterostilbene-Loaded Soluplus/Poloxamer 188 Mixed Micelles for Protection against Acetaminophen-Induced Acute Liver Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00881
Abstract: Excessive acetaminophen (APAP) induces excess reactive oxygen species (ROS), leading to liver damage. Pterostilbene (PTE) has excellent antioxidant and anti-inflammatory activities, but poor solubility limits its biological activity. In this study, we prepared PTE-loaded Soluplus/poloxamer… read more here.
Keywords: liver injury; soluplus poloxamer; poloxamer 188; apap induced ... See more keywords
Modulation of in vitro Brain Endothelium by Mechanical Trauma: Structural and Functional Restoration by Poloxamer 188
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59888-2
Abstract: Brain injuries caused by an explosive blast or blunt force is typically presumed to associate with mechanical trauma to the brain tissue. Recent findings from our laboratory suggest that shockwaves produced by a blast can… read more here.
Keywords: mechanical trauma; structural functional; brain endothelium; poloxamer 188 ... See more keywords
Abstract 22: Poloxamer 188 Protects Mouse Brain Microvascular Endothelial Cells in an in-vitro Traumatic Brain Injury Model
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circ.140.suppl_2.22
Abstract: Introduction: Traumatic brain injury (TBI), a major cause of severe disability and death, can lead to disruption of the vascular endothelial system and cell membrane integrity, threatening the surv... read more here.
Keywords: abstract poloxamer; traumatic brain; poloxamer 188; brain injury ... See more keywords
Abstract 355: Effect of Poloxamer 188 on Rat Brain Isolated Mitochondria After Exposure to Hydrogen Peroxide
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circ.140.suppl_2.355
Abstract: Introduction: In a pig model of myocardial infarction (MI), intracoronary delivered Poloxamer (P) 188 significantly reduces ischemia/reperfusion (IR) injury when given immediately upon reperfusion,... read more here.
Keywords: 188 rat; 355 effect; poloxamer 188; rat brain ... See more keywords
PREPARATION AND EVALUATION OF DOLUTEGRAVIR SOLID DISPERSIONS
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2021v13i1.40113
Abstract: Objective: The current work mainly focuses on solubility enhancement of dolutegravir which is a BCS (Biopharmaceutical Classification System) class-II drug using various excipients. Methods: Solid dispersions of dolutegravir were prepared by solvent evaporation and fusion… read more here.
Keywords: drug; dolutegravir; dolutegravir solid; solid dispersions ... See more keywords
Improving the Solubilization and Bioavailability of Arbidol Hydrochloride by the Preparation of Binary and Ternary β-Cyclodextrin Complexes with Poloxamer 188
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14050411
Abstract: In the current study, the effect of poloxamer 188 on the complexation efficiency and dissolution of arbidol hydrochloride (ADL), a broad-spectrum antiviral agent, with β-cyclodextrin (β-CD) was investigated. Phase solubility studies confirmed a stoichiometry of… read more here.
Keywords: adl; solubilization bioavailability; arbidol hydrochloride; poloxamer 188 ... See more keywords