Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32600
Abstract: Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance. This study explores the role of autophagy in regulating the sensitivity of ovarian… read more here.
Keywords: drug resistance; adenosine diphosphate; poly adenosine; ribose polymerase ... See more keywords
Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors
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DOI: 10.18632/oncotarget.16859
Abstract: Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. Although they have been considered as resident nuclear elements of the… read more here.
Keywords: adenosine diphosphate; poly adp; target; poly adenosine ... See more keywords