Chaperone‐mediated autophagy attenuates H2O2‐induced cardiomyocyte apoptosis by targeting poly (ADP‐ribose) polymerase 1 (PARP1) for lysosomal degradation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11871
Abstract: Poly (ADP‐ribose) polymerase 1 (PARP1) is a typical representative of the PARP enzyme family and is mainly related to DNA repair, gene transcription regulation, inflammation, and oxidative stress. Studies have found that PARP1 is involved… read more here.
Keywords: apoptosis; cma; parp1; degradation ... See more keywords
Targeting cervical cancer: Is there a role for poly (ADP‐ribose) polymerase inhibition?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29440
Abstract: Patients with metastatic and recurrent cervical cancer (CC) have a poor prognosis with limited palliative treatment options. Increasing understanding of the cellular aberrations inherent to cancer cells has allowed the development of therapies to target… read more here.
Keywords: cancer role; poly adp; cervical cancer; ribose polymerase ... See more keywords
Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000856
Abstract: Yanghe decoction is a traditional Chinese medicine prescription and has been used for breast cancer treatment for many years. However, the effective ingredients in the decoction have not been identified. The expression of poly (ADP-ribose)… read more here.
Keywords: ribose polymerase; medicine; adp ribose; poly adp ... See more keywords
Methylmercury induced apoptosis of human neuroblastoma cells through the reactive oxygen species mediated caspase and poly ADP‐ribose polymerase/apoptosis‐inducing factor dependent pathways
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23535
Abstract: Methylmercury (MeHg) is an environmental neurotoxic substance, which can easily cross the blood–brain barrier, causing irreversible damage to the human central nervous system. Reactive oxygen species (ROS) are involved in various ways of intracellular physiological… read more here.
Keywords: reactive oxygen; apoptosis; oxygen species; caspase ... See more keywords
Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations
Sign Up to like & getrecommendations! Published in 2019 at "Drugs"
DOI: 10.1007/s40265-019-01235-5
Abstract: The poly-(ADP-ribose) polymerase (PARP) inhibitors olaparib and talazoparib, have recently been approved for use in patients with metastatic breast cancer (BC) and germline BRCA 1 or 2 mutations due to improved progression-free survival compared to… read more here.
Keywords: poly adp; brca mutations; breast cancer; ribose polymerase ... See more keywords
Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2020 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2019.12.009
Abstract: Disruption of cellular functions with aging-induced accumulation of neuronal stressors causes cell death which is a common feature of neurodegenerative diseases. Studies in a variety of neurodegenerative disease models demonstrate that poly (ADP-ribose) (PAR)-dependent cell… read more here.
Keywords: death; poly adp; neurodegenerative diseases; cell death ... See more keywords
A DNA-encoded library for the identification of natural product binders that modulate poly (ADP-ribose) polymerase 1, a validated anti-cancer target.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.022
Abstract: Natural products have been an invaluable source of drug discovery, but their targets remain largely unknown. Natural products enriched DNA-encoded chemical libraries (nDELs) empower the researchers to rapidly and economically screen numerous natural products against… read more here.
Keywords: poly adp; dna; natural products; dna encoded ... See more keywords
Targeting poly(ADP-ribose) glycohydrolase to draw apoptosis codes in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.004
Abstract: Poly(ADP-ribosyl)ation is a unique post-translational modification of proteins. The metabolism of poly(ADP-ribose) (PAR) is tightly regulated mainly by poly(ADP-ribose) polymerases (PARP) and poly(ADP-ribose) glycohydrolase (PARG). Accumulating evidence has suggested the biological functions of PAR metabolism… read more here.
Keywords: poly adp; dna; cancer; parg ... See more keywords
Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.018
Abstract: The nuclear protein poly(ADP-ribose) polymerases-1/2 (PARP-1/2) are involved in DNA repair damaged by endogenous or exogenous process. And PARP-1/2 inhibitors have been proved to be clinically efficacious for DNA repair deficient tumors in the past… read more here.
Keywords: parp inhibitors; poly adp; carboxamides novel; parp ... See more keywords
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.01.019
Abstract: Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates insoluble protein aggregates in human cells, reminiscent of protein dysfunction in… read more here.
Keywords: protein; poly adp; loss protein; deficiency ... See more keywords
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.04.028
Abstract: Summary ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear. ARH3 is the only hydrolase able to remove serine-linked mono(ADP-ribose) (MAR) but is much less efficient… read more here.
Keywords: ribosylation provides; poly adp; adp ribosylation; provides insights ... See more keywords