Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31328
Abstract: Iron is essential yet also highly chemically reactive and potentially toxic. The mechanisms that allow cells to use iron safely are not clear; defects in iron management are a causative factor in the cell‐death pathway… read more here.
Keywords: iron; poly binding; iron chaperone; binding protein ... See more keywords
Dynamic interaction of poly(A)-binding protein with the ribosome
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35753-1
Abstract: Eukaryotic mRNA has a cap structure and a poly(A) tail at the 5′ and 3′ ends, respectively. The cap structure is recognized by eIF (eukaryotic translation initiation factor) 4 F, while the poly(A) tail is bound… read more here.
Keywords: interaction poly; poly tail; dynamic interaction; poly binding ... See more keywords
Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)‐binding protein 1 in Huntington's disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology"
DOI: 10.1111/neup.12600
Abstract: Huntington's disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the huntingtin protein. Immunohistochemical studies using the 1C2 antibody for polyglutamine expansion have detected characteristic intranuclear inclusions (INIs) in affected… read more here.
Keywords: huntington disease; disease; poly binding; binding protein ... See more keywords
When Poly(A) Binding Proteins Meet Viral Infections, Including SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00136-22
Abstract: Viruses have evolved diverse strategies to hijack the cellular gene expression system for their replication. The poly(A) binding proteins (PABPs), a family of critical gene expression factors, are viruses’ common targets. ABSTRACT Viruses have evolved… read more here.
Keywords: viral infections; poly binding; binding proteins; gene expression ... See more keywords
Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00175-18
Abstract: Formation of the mammalian hematopoietic system is under a complex set of developmental controls. Here, we report that mouse embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid… read more here.
Keywords: runx1; protein pcbp2; pcbp2; poly binding ... See more keywords
Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein–mediated viral translation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.142805
Abstract: Diabetes mellitus (DM) is highly comorbid with severe dengue diseases; however, the underlying mechanisms are unclear. Patients with DM have a 1.61-fold increased risk of developing dengue hemorrhagic fever. In search of host factors involved… read more here.
Keywords: viral translation; infection; poly binding; dengue virus ... See more keywords
Poly(rC) binding protein 1 represses the translation of STAT3 through 5' UTR.
Sign Up to like & getrecommendations! Published in 2022 at "Current gene therapy"
DOI: 10.2174/1566523222666220511162934
Abstract: BACKGROUND Signal transducer and activator of transcription 3 (STAT3) is an oncogene and frequently overexpressed in cancers. However, the regulatory mechanisms of STAT3 expression are not fully understood. Poly(rC)-binding protein1 (PCBP1) is an RNA-binding protein… read more here.
Keywords: stat3; expression; pcbp1; poly binding ... See more keywords
Poly C Binding Protein 1 Regulates p62/SQSTM1 mRNA Stability and Autophagic Degradation to Repress Tumor Progression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00930
Abstract: Accumulating evidence show that Poly C Binding Protein 1 (PCBP1) is deleted in distinct types of tumors as a novel tumor suppressor, but its tumor suppression mechanism remains elusive. Here, we firstly describe that downregulation… read more here.
Keywords: tumor progression; tumor; p62 sqstm1; poly binding ... See more keywords
Poly(rC)-binding proteins as pleiotropic regulators in hematopoiesis and hematological malignancy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1045797
Abstract: Poly(rC)-binding proteins (PCBPs), a defined subfamily of RNA binding proteins, are characterized by their high affinity and sequence-specific interaction with poly-cytosine (poly-C). The PCBP family comprises five members, including hnRNP K and PCBP1-4. These proteins… read more here.
Keywords: regulators hematopoiesis; poly binding; binding proteins; pleiotropic regulators ... See more keywords