Sidechain Engineering in Cell-Penetrating Poly(disulfide)s
Sign Up to like & getrecommendations! Published in 2017 at "Helvetica Chimica Acta"
DOI: 10.1002/hlca.201600370
Abstract: Cell-penetrating poly(disulfide)s (CPDs) have been introduced recently to explore new ways to enter into cells. In this report, we disclose a general method to covalently modify the sidechains of CPDs. Compatibility of copper-catalyzed alkyne-azide cycloaddition… read more here.
Keywords: disulfide; penetrating poly; cell penetrating; poly disulfide ... See more keywords
Amplification of tumor oxidative stresses by Poly(disulfide acetal) for multidrug resistance reversal.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121005
Abstract: Discovering new strategies to overcome multidrug resistance (MDR) is still urgently needed. MDR is associated with the overexpression of transmembrane efflux pumps, and adenosine triphosphate (ATP) is indispensable for its function. Herein, we developed a… read more here.
Keywords: disulfide acetal; resistance; multidrug resistance; cancer ... See more keywords
Bioderived Lipoic Acid-Based Dynamic Covalent Nanonetworks of Poly(disulfide)s: Enhanced Encapsulation Stability and Cancer Cell-Selective Delivery of Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00493
Abstract: Dynamic covalent poly(disulfide)-based cross-linked nanoaggregates, termed nanonetworks (NNs), endowed with pH- and redox-responsive degradation features have been fabricated for stable noncovalent encapsulation and triggered cargo release in a controlled fashion. A bioderived lipoic acid-based Gemini… read more here.
Keywords: dynamic covalent; cell selective; encapsulation; stability ... See more keywords
Lipoic Acid-Based Poly(disulfide)s as Versatile Biomolecule Delivery Vectors and the Application in Tumor Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00231
Abstract: Intracellular delivery of therapeutic biomacromolecules, including nucleic acids and proteins, attracts extensive attention in biotherapeutics for various diseases. Herein, a strategy is proposed for the construction of poly(disulfide)s for the efficient delivery of both nucleic… read more here.
Keywords: lipoic acid; poly disulfide; immunotherapy; tumor ... See more keywords
Architecture-Controlled Ring-Opening Polymerization for Dynamic Covalent Poly(disulfide)s.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b08957
Abstract: A strategy is reported for controlling the architecture of poly(disulfide)s by ring-opening polymerization. Aryl thiol initiators shift the ring-chain equilibrium to yield cyclic polymers while alkyl thiols favor linear ones. Control over polymerization enables the… read more here.
Keywords: ring opening; polymerization; opening polymerization; dynamic covalent ... See more keywords
In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06840g
Abstract: Cell-penetrating poly(disulfide)s (CPDs) are promising vehicles for cytosolic delivery of proteins. However, currently available arginine-rich CPD has rarely been reported for systemic delivery due to its "always" positive charge. Herein, we developed pH-responsive CPDIMD that… read more here.
Keywords: cell penetrating; delivery; penetrating poly; poly disulfide ... See more keywords
Cell-penetrating poly(disulfide)-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07020g
Abstract: Monitoring gene delivery has significant benefits in gene therapy. Herein, we report a nanoquencher system by doping a FRET pair during nucleic acid-assisted cell penetrating poly(disulfide) (CPD) formation. Our results show that this strategy not… read more here.
Keywords: cell penetrating; penetrating poly; gene delivery; gene ... See more keywords
Facile synthesis of poly(disulfide)s through one-step oxidation polymerization for redox-responsive drug delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d3bm00461a
Abstract: Poly(disulfide)s-based systems with repetitive disulfide bonds in their backbones are emerging as promising tumor microenvironment responsive platforms for drug delivery. However, complicated synthesis and purification processes have restricted their further application. Herein, we developed redox-responsive… read more here.
Keywords: redox responsive; poly disulfide; pbdbm nps; drug delivery ... See more keywords