Activation of EP2 receptor suppresses poly(I: C) and LPS‐mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for MAPKs
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DOI: 10.1002/glia.23276
Abstract: Brain inflammation is a critical factor involved in neurodegeneration. Recently, the prostaglandin E2 (PGE2) downstream members were suggested to modulate neuroinflammatory responses accompanying neurodegenerative diseases. In this study, we investigated the protective effects of prostaglandin… read more here.
Keywords: ep2 receptor; primary microglia; organotypic hippocampal; hippocampal slice ... See more keywords
Ibrutinib Prevents Acute Lung Injury via Multi-Targeting BTK, FLT3 and EGFR in Mice
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DOI: 10.3390/ijms232113478
Abstract: Ibrutinib has potential therapeutic or protective effects against viral- and bacterial-induced acute lung injury (ALI), likely by modulating the Bruton tyrosine kinase (BTK) signaling pathway. However, ibrutinib has multi-target effects. Moreover, immunity and inflammation targets… read more here.
Keywords: acute lung; flt3 egfr; lung injury; poly lps ... See more keywords