Effective mRNA Protection by Poly(L-Ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer Toward Maximizing mRNA Introduction Efficiency.
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DOI: 10.1002/marc.202100754
Abstract: For efficient delivery of messenger (m)RNA, delivery carriers need two major functions: protecting mRNA from nucleases and translocating mRNA from endolysosomes to the cytoplasm. Herein, these two complementary functionalities were integrated into a single polyplex… read more here.
Keywords: mrna polyplex; endosomal escape; charge conversion; poly ornithine ... See more keywords
Poly(l-Ornithine)-Based Polymeric Micelles as pH-Responsive Macromolecular Anticancer Agents
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DOI: 10.3390/pharmaceutics15041307
Abstract: Anticancer peptides and polymers represent an emerging field of tumor treatment and can physically interact with tumor cells to address the problem of multidrug resistance. In the present study, poly(l-ornithine)-b-poly(l-phenylalanine) (PLO-b-PLF) block copolypeptides were prepared… read more here.
Keywords: plo; macromolecular anticancer; poly ornithine; anticancer ... See more keywords
Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair
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DOI: 10.4103/1673-5374.353493
Abstract: The extracellular matrix surrounding oligodendrocytes plays an important role during myelination and remyelination in the brain. In many cases, the microenvironment surrounding demyelination lesions contains inhibitory molecules, which lead to repair failure. Accordingly, blocking the… read more here.
Keywords: oligodendrocyte differentiation; inhibitory effects; poly ornithine; ornithine ... See more keywords