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Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02154-6
Abstract: GGG GCC (G4C2) repeat expansion in the first intron of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [6, 11]. Brain tissues from affected individuals show characteristic…
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Keywords:
repeat;
deletion;
c9orf72;
poly poly ... See more keywords
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1
Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.01.004
Abstract: Triple-helical RNA are of interest because of possible biological roles as well as the potential therapeutic uses of these structures, while the stability of triplexes is usually weaker than that of the Watson-Crick base pairing…
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Keywords:
bpy pip;
poly triplex;
poly;
poly poly ... See more keywords
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Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.110705
Abstract: In this work, two Ru(II)-dppz (dppz = dipyrido[3,2-a:2',3'-c]phenazine) complexes containing fluorine substituents, [Ru(bpy)2(7-F-dppz)]2+ (Ru1, bpy = 2,2'-bipyridine, 7-F-dppz = 7-fluorodipyrido[3,2-a:2',3'-c]phenazine) and [Ru(phen)2(7-F-dppz)]2+ (Ru2, phen = 1,10-phenanthroline), have been synthesized and characterized. Binding properties of Ru1 and Ru2 with the RNA poly(U)·poly(A) ∗ poly(U) triplex have…
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Keywords:
poly poly;
poly triplex;
dppz;
complexes containing ... See more keywords
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1
Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111268
Abstract: The association of two ruthenium(II) complexes [Ru(phen)2(o-HPIP)]2+ (Ru1; phen = 1,10-phenanthroline, o-HPIP = 2-(2-hydroxyphenyl)-imidazo[4,5-f][1,10] phenanthroline) and [Ru(phen)2(m-HPIP)]2+ (Ru2; m-HPIP = 2-(3-hydroxyphenyl)-imidazo[4,5-f][1,10]phenan- throline) with the RNA poly(U)·poly(A)⁎poly(U) triplex has been investigated by spectrophotometric titrations and melting…
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Keywords:
phen hpip;
poly triplex;
poly;
effect ... See more keywords
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Published in 2021 at "Polymer"
DOI: 10.1016/j.polymer.2020.123305
Abstract: Abstract: Gas separation using separation membranes is highly advantageous as they consume less energy and are environmentally friendly and inexpensive. Substituted poly(diarylacetylene)s are potential materials for gas-separation membrane owing to the excellent permeation performance. Herein,…
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Keywords:
gas;
permeability;
poly poly;
separation ... See more keywords
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1
Published in 2017 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b00670
Abstract: The first investigation of chiral ruthenium(II) complexes Δ- and Λ-[Ru(bpy)2dppz]2+ and triplex RNA poly(U)·poly(A)*poly(U) was carried out, which showed that Δ enantiomer displayed significant ability in stabilizing model triplex RNA.
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Keywords:
bpy 2dppz;
poly;
poly poly;
binding differences ... See more keywords
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Published in 2019 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-019-0310-z
Abstract: BackgroundA G4C2 hexanucleotide repeat expansion in the noncoding region of C9orf72 is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). Putative disease mechanisms underlying c9FTD/ALS include toxicity from sense G4C2 and…
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Keywords:
stress granule;
deposition;
poly poly;
stress ... See more keywords