Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs.
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DOI: 10.1007/s11357-022-00533-3
Abstract: Dogs may possess a unique translational potential to investigate neural aging and dementia because they are prone to age-related cognitive decline, including an Alzheimer's disease-like pathological condition. Yet very little is known about the molecular… read more here.
Keywords: age; rna sequencing; reveals age; age related ... See more keywords
Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A)+ RNA foci adjacent to nuclear speckles following activation of ATM (ataxia telangiectasia mutated)
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DOI: 10.1080/15476286.2022.2146919
Abstract: ABSTRACT Intracellular and intercellular signalling networks play an essential role in optimizing cellular homoeostasis and are thought to be partly reflected in nuclear mRNA dynamics. However, the regulation of nuclear mRNA dynamics by intracellular and… read more here.
Keywords: rna; nuclear speckles; poly rna; complex iii ... See more keywords
Structural basis of 3′-end poly(A) RNA recognition by LARP1
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DOI: 10.1093/nar/gkac696
Abstract: Abstract La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA-binding domains, La motif (LaM) and RNA recognition motif… read more here.
Keywords: rna; rna recognition; poly rna; poly ... See more keywords