Birth of a poly(A) tail: Mechanisms and control of mRNA polyadenylation.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS open bio"
DOI: 10.1002/2211-5463.13528
Abstract: During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two-step 3'-end processing reaction in which the pre-mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail… read more here.
Keywords: poly tail; birth poly; polyadenylation; end processing ... See more keywords
Measurement of mRNA Poly(A) Tail Lengths in Drosophila Female Germ Cells and Germ-Line Stem Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-4017-2_7
Abstract: mRNA regulation by poly(A) tail length variations plays an important role in many developmental processes. Recent advances have shown that, in particular, deadenylation (the shortening of mRNA poly(A) tails) is essential for germ-line stem cell… read more here.
Keywords: germ line; mrna poly; line stem; poly tail ... See more keywords
Different roles for the adjoining and structurally similar A-rich and poly(A) domains of oskar mRNA: Only the A-rich domain is required for oskar noncoding RNA function, which includes MTOC positioning.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.03.021
Abstract: Drosophila oskar (osk) mRNA has both coding and noncoding functions, with the latter required for progression through oogenesis. Noncoding activity is mediated by the osk 3' UTR. Three types of cis elements act most directly… read more here.
Keywords: function; poly tail; osk noncoding; osk mrna ... See more keywords
Dynamic interaction of poly(A)-binding protein with the ribosome
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35753-1
Abstract: Eukaryotic mRNA has a cap structure and a poly(A) tail at the 5′ and 3′ ends, respectively. The cap structure is recognized by eIF (eukaryotic translation initiation factor) 4 F, while the poly(A) tail is bound… read more here.
Keywords: interaction poly; poly tail; dynamic interaction; poly binding ... See more keywords
PolyAtailor: measuring poly(A) tail length from short-read and long-read sequencing data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac271
Abstract: The poly(A) tail is a dynamic addition to the eukaryotic mRNA and the change in its length plays an essential role in regulating gene expression through affecting nuclear export, mRNA stability and translation. Only recently… read more here.
Keywords: tail length; poly tail; tail; polyatailor ... See more keywords
Interplay between the Poly(A) Tail, Poly(A)-Binding Protein, and Coronavirus Nucleocapsid Protein Regulates Gene Expression of Coronavirus and the Host Cell
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01162-18
Abstract: Gene expression in coronavirus is a complicated and dynamic process. In this study, we demonstrated that coronavirus N protein is able to bind to the poly(A) tail with high affinity, establishing N protein as a… read more here.
Keywords: protein; poly tail; coronavirus; gene expression ... See more keywords
tailfindr: Alignment-free poly(A) length measurement for Oxford Nanopore RNA and DNA sequencing.
Sign Up to like & getrecommendations! Published in 2019 at "RNA"
DOI: 10.1261/rna.071332.119
Abstract: Polyadenylation at the 3'-end is a major regulator of messenger RNA and its length is known to affect nuclear export, stability and translation, among others. Only recently, strategies have emerged that allow for genome-wide poly(A)… read more here.
Keywords: length; poly; poly tail; poly length ... See more keywords
Oppositional Poly(A) Tail Length Regulation by FMRP and CPEB1.
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079050.121
Abstract: Poly(A) tail length is regulated in both the nucleus and cytoplasm. One factor that controls polyadenylation in the cytoplasm is CPEB1, an RNA binding protein that associates with specific mRNA 3'UTR sequences to tether enzymes… read more here.
Keywords: tail length; poly tail; poly; fmrp ... See more keywords
Translation termination-dependent deadenylation of MYC mRNA in human cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25459
Abstract: The earliest step in the mRNA degradation process is deadenylation, a progressive shortening of the mRNA poly(A) tail by deadenylases. The question of when deadenylation takes place remains open. MYC mRNA is one of the… read more here.
Keywords: poly tail; translation termination; myc mrna; myc ... See more keywords
Heat Shock Responsive Gene Expression Modulated by mRNA Poly(A) Tail Length
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.01255
Abstract: Poly(A) tail length (PAL) has been implicated in the regulation of mRNA translation activities. However, the extent of such regulation at the transcriptome level is less understood in plants. Herein, we report the development and… read more here.
Keywords: tail length; poly tail; heat shock; stress ... See more keywords
Encapsulation of mRNA into Artificial Viral Capsids via Hybridization of a β-Annulus-dT20 Conjugate and the Poly(A) Tail of mRNA
Sign Up to like & getrecommendations! Published in 2020 at "Applied Sciences"
DOI: 10.3390/app10228004
Abstract: Messenger RNA (mRNA) drugs have attracted considerable attention as promising tools with many therapeutic applications. The efficient delivery of mRNA drugs using non-viral materials is currently being explored. We demonstrate a novel concept where mCherry… read more here.
Keywords: poly tail; encapsulation mrna; via hybridization; mrna ... See more keywords