Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression.
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DOI: 10.1261/rna.077099.120
Abstract: Chemical modifications enable preparation of mRNAs with augmented stability and translational activity. In this study, we explored how chemical modifications of 5',3'-phosphodiester bonds in the mRNA body and polyA tail influence the biological properties of… read more here.
Keywords: tail prevent; polya tail; modifications mrna; mrna polya ... See more keywords