Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6817-6_12
Abstract: Alternative polyadenylation is increasingly being recognized as an important layer of gene regulation. Antisense-mediated modulation of alternative polyadenylation represents an attractive strategy for the regulation of gene expression as well as potential therapeutic applications. In… read more here.
Keywords: expression blocking; isoform expression; polyadenylation; polyadenylation signal ... See more keywords
Slight Variations in the Sequence Downstream of the Polyadenylation Signal Significantly Increase Transgene Expression in HEK293T and CHO Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415485
Abstract: Compared to transcription initiation, much less is known about transcription termination. In particular, large-scale mutagenesis studies have, so far, primarily concentrated on promoter and enhancer, but not terminator sequences. Here, we used a massively parallel… read more here.
Keywords: downstream polyadenylation; hek293t cho; polyadenylation signal; hek293t ... See more keywords