New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103560
Abstract: Candida glabrata, the most common non-albicans Candida species and one of the primary causes of candidemia, exhibits decreased susceptibility to azoles and more recently to echinocandins. Polyalthic acid 1, a furan diterpene, has been shown… read more here.
Keywords: glabrata produced; ent; produced microbial; polyalthic acid ... See more keywords
Polyalthic Acid in Polymeric Nanoparticles Causes Selective Growth Inhibition and Genotoxicity in MCF-7 Cells
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Communications"
DOI: 10.1177/1934578x19842702
Abstract: Polyalthic acid (PA) is a diterpene present in several trees of the Copaifera genus, with reported antitumor activity but poor water solubility. The aim of this work was the incorporation of PA in polymeric nanoparticles… read more here.
Keywords: polymeric nanoparticles; mcf cells; acid polymeric; mcf ... See more keywords