Analysis of Cotranslational Polyamine Sensing During Decoding of ODC Antizyme mRNA.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7398-9_26
Abstract: Polyamines are essential poly-cations with vital functions in all cellular systems. Their levels are controlled by intricate regulatory feedback mechanisms. Abnormally high levels of polyamines have been linked to cancer. A rate-limiting enzyme in the… read more here.
Keywords: analysis cotranslational; odc antizyme; polyamine sensing; polyamine ... See more keywords
Polyamine nanogel particles spray-coated on carbon paper for efficient CO2 capture in a milli-channel reactor
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2020.126059
Abstract: Abstract In this work, we report a proof-of-concept study on CO2 adsorbents synthesized by a thermally initiated free-radical copolymerization and then coated onto carbon paper and poly tetra fluoroethylene via a spray coating approach. A… read more here.
Keywords: milli channel; co2 capture; paper; polyamine ... See more keywords
Electrodeposition from Tannic acid-polyamine blends at pH = 5.0 is due to aggregate deposition and oxidation
Sign Up to like & getrecommendations! Published in 2019 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2019.05.091
Abstract: Abstract Polyphenols like tannic acid, and others, adsorb spontaneously to the surface of a vast repertoire of materials to coat them with a conformal and functional thin film. Since polyphenols can be oxidized, their deposition… read more here.
Keywords: tannic acid; oxidation; deposition; polyamine ... See more keywords
Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113586
Abstract: The aim of this study was to synthesize chalcone-polyamine conjugates in order to enhance bioavailability and selectivity of chalcone core towards cancer cells, using polyamine-based vectors. Indeed, it is well-known that polyamine transport system is… read more here.
Keywords: prostate cancer; polyamine; polyamine conjugates; chalcone polyamine ... See more keywords
Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e05031
Abstract: The polyamines spermidine, spermine and putrescine are essential for normal cellular functions. The contents of polyamines in tissue decreased in aged mice compared to young mice. In this study, the polyamine contents and their metabolic… read more here.
Keywords: conjugated lysine; acrolein conjugated; age; polyamine ... See more keywords
Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.002
Abstract: Mutations in ATP13A2, also known as PARK9, cause a rare monogenic form of juvenile-onset Parkinson's disease named Kufor-Rakeb syndrome and other neurodegenerative diseases. ATP13A2 encodes a neuroprotective P5B P-type ATPase highly enriched in the brain… read more here.
Keywords: gating ion; structural mechanisms; polyamine; ion ... See more keywords
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.11.001
Abstract: The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations, regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a lysosomal polyamine exporter responsible for polyamine release into the cytosol, and its dysfunction… read more here.
Keywords: reveals mechanistic; human atp13a2; polyamine; cryo reveals ... See more keywords
Polysaccharide extracts of Astragalus membranaceus and Atractylodes macrocephala promote intestinal epithelial cell migration by activating the polyamine-mediated K+ channel.
Sign Up to like & getrecommendations! Published in 2018 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(18)30107-9
Abstract: Astragalus membranaceus (Radix Astragali, RA) and Atractylodes macrocephala (Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of polysaccharides extracts from these two herbs on… read more here.
Keywords: astragalus membranaceus; polysaccharide extracts; cell migration; polyamine ... See more keywords
Discovery of the Polyamine Conjugate with Benzo[ cd]indol-2(1 H)-one as a Lysosome-Targeted Antimetastatic Agent.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00694
Abstract: Polyamine derivatives have a promising prospect in dealing with disseminated tumor cells, a major obstacle in cancer therapy. To develop a bifunctional polyamine derivative that can serve as a fluorescent probe and an antimetastatic agent,… read more here.
Keywords: indol one; discovery polyamine; polyamine; benzo indol ... See more keywords
Design and Evaluation of Potent EGFR Inhibitors through the Incorporation of Macrocyclic Polyamine Moieties into the 4-Anilinoquinazoline Scaffold.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01612
Abstract: Adenosine triphosphate (ATP)-competitive inhibitors of the epidermal growth factor receptor (EGFR) have provided a significant improvement in the disease outcome of nonsmall cell lung cancer (NSCLC). Unfortunately, some marketed drugs affect a transient beneficial response… read more here.
Keywords: anilinoquinazoline scaffold; macrocyclic polyamine; incorporation macrocyclic; egfr inhibitors ... See more keywords
Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00362
Abstract: The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that otherwise attenuates the efficacy of cytotoxic cancer chemotherapy… read more here.
Keywords: selective inhibition; polyamine deacetylase; hdac10; polyamine ... See more keywords