Articles with "polyamine blockade" as a keyword



Abstract 5283: Polyamine blockade therapy: A strategy to block immunosuppression in pancreatic cancer

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Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-5283

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients and is characterized by a dense tumor microenvironment (TME) which impedes tumor entry of immune cells and delivery of therapeutics. Immunosuppressive myeloid populations of PDAC,… read more here.

Keywords: cancer; polyamine blockade; tumor; immunosuppression ... See more keywords