Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase.
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DOI: 10.1021/acschembio.0c00362
Abstract: The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that otherwise attenuates the efficacy of cytotoxic cancer chemotherapy… read more here.
Keywords: selective inhibition; polyamine deacetylase; hdac10; polyamine ... See more keywords