Conserved but not critical: Trafficking and function of NaV1.7 are independent of highly conserved polybasic motifs
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1161028
Abstract: Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral voltage-gated sodium (NaV) channels are an attractive target for pain therapy because they initiate and propagate action potentials in primary afferents that detect… read more here.
Keywords: rab6a; polybasic motifs; trafficking function; critical trafficking ... See more keywords
Bluetongue Virus Nonstructural Protein 3 Orchestrates Virus Maturation and Drives Non-Lytic Egress via Two Polybasic Motifs
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11121107
Abstract: Bluetongue virus (BTV) is an arthropod-borne virus that infects domestic and wild ruminants. The virion is a non-enveloped double-layered particle with an outer capsid that encloses a core containing the segmented double-stranded RNA genome. Although… read more here.
Keywords: non lytic; two polybasic; polybasic motifs; lytic egress ... See more keywords