Global koff‐rates of polyclonal T‐cell populations merge subclonal avidities and predict functionality
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149597
Abstract: The avidity of TCRs for peptide‐major histocompatibility complexes (pMHCs) is a governing factor in how T cells respond to antigen. TCR avidity is generally linked to T‐cell functionality and there is growing evidence for distinct… read more here.
Keywords: cell; cell populations; koff rates; avidity ... See more keywords
Absence of driver mutations in persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-03-776674
Abstract: To the editor: Most hematologic malignancies are preceded by a premalignant condition. In myeloid neoplasms, genetically defined premalignant conditions such as clonal hematopoiesis of indeterminate potential[1][1] reflect the clonal dominance of hematopoietic stem cells harboring… read more here.
Keywords: mutations persistent; absence driver; persistent polyclonal; polyclonal cell ... See more keywords
Clinical course and features of persistent polyclonal B-cell lymphocytosis with BCL-6 amplification during pregnancy.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202304_32124
Abstract: BACKGROUND Persistent polyclonal B-cell lymphocytosis is a rare nonmalignant disorder characterized by mild persistent lymphocyte proliferation with possible evolution to aggressive lymphoma. Its biology is not well known, but it is characterized by a specific… read more here.
Keywords: persistent polyclonal; cell lymphocytosis; amplification; pregnancy ... See more keywords