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   Articles with "polycomb" as a keyword



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Polycomb complex mediated epigenetic reprogramming alters TGF‐β signaling via a novel EZH2/miR‐490/TGIF2 axis thereby inducing migration and EMT potential in glioblastomas

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recommendations! Published in 2019 at "International Journal of Cancer"

DOI: 10.1002/ijc.32360

Abstract: Recent advancement in understanding cancer etiology has highlighted epigenetic deregulation as an important phenomenon leading to poor prognosis in glioblastoma (GBM). Polycomb repressive complex 2 (PRC2) is one such important epigenetic modifier reportedly altered in… read more here.

Keywords: mir 490; migration emt; gbm; polycomb ... See more keywords
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Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

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recommendations! Published in 2017 at "Cell"

DOI: 10.1016/j.cell.2017.08.002

Abstract: Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recently, they have been shown… read more here.

Keywords: polycomb; polycomb trithorax; regulation polycomb; trithorax years ... See more keywords
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Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

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recommendations! Published in 2019 at "Molecular Cell"

DOI: 10.1016/j.molcel.2019.03.024

Abstract: Summary The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic.… read more here.

Keywords: gene repression; variant prc1; polycomb; repression ... See more keywords
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JASMONATE-ZIM DOMAIN proteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis.

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recommendations! Published in 2021 at "Molecular plant"

DOI: 10.1016/j.molp.2021.03.001

Abstract: Jasmonate (JA) regulates various aspects of plant growth and development and stress responses, with prominent roles in male reproductive development and defenses against herbivores and necrotrophic pathogens. JASMONATE-ZIM DOMAIN (JAZ) proteins are key regulators in… read more here.

Keywords: zim domain; jasmonate zim; polycomb; chromatin ... See more keywords
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Digital paradigm for Polycomb epigenetic switching and memory

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recommendations! Published in 2021 at "Current Opinion in Plant Biology"

DOI: 10.1016/j.pbi.2021.102012

Abstract: How epigenetic memory states are established and maintained is a central question in gene regulation. A major epigenetic process important for developmental biology involves Polycomb-mediated chromatin silencing. Significant progress has recently been made on elucidating… read more here.

Keywords: polycomb; paradigm polycomb; biology; polycomb epigenetic ... See more keywords
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Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.

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recommendations! Published in 2018 at "Developmental biology"

DOI: 10.1016/j.ydbio.2017.11.004

Abstract: Polycomb repressive complexes maintain transcriptional repression of genes encoding crucial developmental regulators through chromatin modification. Here we investigated the role of Polycomb repressive complex 2 (PRC2) in retinal development by inactivating its key components Eed… read more here.

Keywords: retinal differentiation; polycomb; progenitor cells; retinal progenitor ... See more keywords
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Polycomb repressive complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia

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recommendations! Published in 2018 at "Leukemia"

DOI: 10.1038/s41375-018-0187-9

Abstract: Human polycomb proteins exert their epigenetic functions as part of nuclear multimeric complexes, of which Polycomb Repressive Complexes PRC1 and PRC2 are the best characterized [1]. A variety of alterations in Polycomb protein level and… read more here.

Keywords: polycomb repressive; myeloid leukemia; polycomb; acute myeloid ... See more keywords
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Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration

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recommendations! Published in 2018 at "Cell Death and Differentiation"

DOI: 10.1038/s41418-018-0064-0

Abstract: Neurons in the central nervous system (CNS) lose their intrinsic ability and fail to regenerate, but the underlying mechanisms are largely unknown. Polycomb group (PcG) proteins, which include PRC1 and PRC2 complexes function as gene… read more here.

Keywords: growth regeneration; axon growth; polycomb; regeneration ... See more keywords
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Mitochondria-targeting nano therapy altering IDH2-mediated EZH2/EZH1 interaction as precise epigenetic regulation in glioblastoma.

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recommendations! Published in 2022 at "Biomaterials science"

DOI: 10.1039/d1bm02006d

Abstract: Glioblastoma (GBM) is a complex brain cancer with frequent relapses and high mortality and still awaits effective treatment. Mitochondria dysfunction is a pathogenic condition in GBM and could be a prime therapeutic target for ceasing… read more here.

Keywords: interaction; glioblastoma; polycomb; therapy ... See more keywords
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Bivalency in Drosophila embryos is associated with strong inducibility of Polycomb target genes

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recommendations! Published in 2019 at "Fly"

DOI: 10.1080/19336934.2019.1619438

Abstract: ABSTRACT Polycomb group (PcG) and Trithorax group (TrxG) proteins orchestrate development of a multicellular organism by faithfully maintaining cell fate decisions made early in embryogenesis. An important chromatin mark connected to PcG/TrxG regulation is bivalent… read more here.

Keywords: bivalency; polycomb; drosophila embryos; inducibility ... See more keywords
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Hierarchical recruitment of Polycomb complexes revisited

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recommendations! Published in 2017 at "Nucleus"

DOI: 10.1080/19491034.2017.1363136

Abstract: ABSTRACT Polycomb Group (PcG) proteins epigenetically repress key developmental genes and thereby control alternative cell fates. PcG proteins act as complexes that can modify histones and these histone modifications play a role in transmitting the… read more here.

Keywords: polycomb; histone modifications; pcg complexes; hierarchical recruitment ... See more keywords