EXTH-27. POLYCOMB OVERACTIVITY DRIVES TUMORIGENESIS IN AGGRESSIVE CUSHING’S DISEASE
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DOI: 10.1093/neuonc/noae165.0958
Abstract: Aggressive Cushing’s disease (CD) tumors (Ki67 > 3%) exhibit rapid growth, poor postsurgical outcomes, and resistance to conventional therapies. Polycomb group (PcG) proteins are canonical epigenetic silencers that can drive tumor aggressiveness. We asked if… read more here.
Keywords: cushing disease; polycomb overactivity; aggressive cushing; pcg ... See more keywords