An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2019.03.018
Abstract: Summary Adenine N6 methylation in DNA (6mA) is widespread among bacteria and phage and is detected in mammalian genomes, where its function is largely unexplored. Here we show that 6mA deposition and removal are catalyzed… read more here.
Keywords: preserves polycomb; polycomb silencing; network; adversarial dna ... See more keywords
The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1129
Abstract: Abstract The Polycomb repressive complex 2 (PRC2) catalyzes histone H3 Lys27 trimethylation (H3K27me3) to repress gene transcription in multicellular eukaryotes. Despite its importance in gene silencing and cellular differentiation, how PRC2 is recruited to target… read more here.
Keywords: polycomb silencing; genome wide; clf; val1 val2 ... See more keywords
Distinct roles for canonical and variant histone H3 lysine-36 in Polycomb silencing
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf2451
Abstract: Polycomb complexes regulate cell-type specific gene expression programs through heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is essential for this process. Perturbation of H3K36 is thought to interfere with H3K27me3.… read more here.
Keywords: histone lysine; polycomb silencing; histone; distinct roles ... See more keywords
The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-11-815035
Abstract: Eleven-nineteen leukemia (ENL) is a chromatin reader present in complexes stimulating transcriptional elongation. It is fused to mixed-lineage leukemia (MLL) in leukemia, and missense mutations have been identified in Wilms tumor and acute myeloid leukemia.… read more here.
Keywords: polycomb silencing; paf1; leukemia; interaction enl ... See more keywords