A Diastereoselective Cascade Annulation Approach to Bridged Polycyclic Heterocycles Involving an Unexpected Rearrangement.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03629
Abstract: A diastereoselective cascade annulation between allenoates and in-situ generated isoquinoline N-oxides generating sp3-rich bridged polycyclic heterocycles is disclosed. The reaction proceeds through an unprecedented non-rearomatized rearrangement and allows access to a broad range of bridged… read more here.
Keywords: bridged polycyclic; cascade annulation; diastereoselective cascade; polycyclic heterocycles ... See more keywords
Synthesis of chiral polycyclic N-heterocycles via gold(I)-catalyzed 1,6-enyne cyclization/intramolecular nucleophilic addition.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06388j
Abstract: Cycloisomerization of N-tethered indole- and dihydropyrrole-arylpropargyl substrates into complex polycycles was investigated by using gold(I) catalysis. Enantioselectivities up to 93% ee were obtained in the asymmetric version of this process. DFT calculations rationalized the reactivity… read more here.
Keywords: heterocycles via; polycyclic heterocycles; synthesis chiral; chiral polycyclic ... See more keywords