Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies
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DOI: 10.1002/ptr.7497
Abstract: Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities, including neuroprotective properties, exerting preventive and/or therapeutic effects in central nervous system (CNS) disorders. In the present study,… read more here.
Keywords: review; central nervous; systematic review; polydatin ... See more keywords
Polydatin alleviates DSS‐ and TNBS‐induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3
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DOI: 10.1002/ptr.7533
Abstract: Inflammatory bowel disease (IBD) is a non‐specific chronic intestinal inflammatory disease, often presenting with abdominal pain, diarrhea, bloody stool, anorexia, and body loss. It is difficult to cure completely and a promising treatment is urgently… read more here.
Keywords: stat3; th17; colitis; polydatin ... See more keywords
Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-018-1241-7
Abstract: Polydatin is a traditional Chinese medicine that provides myocardial protection after acute myocardial infarction (AMI). The study aim was to investigate the myocardial protection polydatin in H9c2 myocardial cells cultured in a hypoxic atmosphere and… read more here.
Keywords: myocardial infarction; nrf2 signaling; polydatin; damage ... See more keywords
Cloning, biochemical characterization and molecular docking of novel thermostable β-glucosidase BglA9 from Anoxybacillus Ayderensis A9 and its application in de-glycosylation of Polydatin.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.11.021
Abstract: This study reports a novel BglA9 gene of 1345 bp encoding β-glucosidase from Anoxybacillus ayderensis A9, which was amplified and expressed in E. coli BL21 (DE3): pLysS cells, purified with Ni-NTA column having molecular weight of… read more here.
Keywords: bgla9; anoxybacillus ayderensis; glycosylation; polydatin ... See more keywords
Highly efficient enzymatic synthesis of novel polydatin prodrugs with potential anticancer activity
Sign Up to like & getrecommendations! Published in 2017 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2016.09.028
Abstract: Abstract Efficient lipase-mediated research work was successfully exploited for synthesizing potential 6″- O -acyl-polydatin prodrugs in biomass-derived 2-methyltetrahydrofuran (2-MeTHF). The results of the enzyme recognitions of nine acyl donors evidently demonstrated that the position and… read more here.
Keywords: synthesis novel; enzymatic synthesis; polydatin prodrugs; polydatin ... See more keywords
Corrigendum to “Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway” [Redox Biol. 18 (2018) 124–137]
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DOI: 10.1016/j.redox.2019.101101
Abstract: The authors regret In the article referenced above, a picture error was inadvertently introduced during the course of revision. There was a copy and paste error in Fig. 1C where the right-most column of representative… read more here.
Keywords: corrigendum polydatin; corrigendum; polydatin prevents; prevents fructose ... See more keywords
De Novo Biosynthesis of Polydatin in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c01557
Abstract: Polydatin, with better structural stability and biological activities than resveratrol, is mainly extracted from the traditional Chinese medicinal plant Polygonum cuspidatum. In this study, based on the transcriptome analysis of P. cuspidatum, we identified the… read more here.
Keywords: biosynthesis; saccharomyces cerevisiae; novo biosynthesis; polydatin saccharomyces ... See more keywords
Polydatin-Induced Direct and Bystander Effects in A549 Lung Cancer Cell Line.
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DOI: 10.1080/01635581.2020.1870705
Abstract: Polydatin, a natural analogue of resveratrol, has many biological activities. The better bioavailability of polydatin than resveratrol makes it an ideal candidate for therapy. Polydatin has protective effects against various diseases (cardiovascular, neurological, inflammatory, etc.)… read more here.
Keywords: a549 cells; polydatin; lung cancer; cancer ... See more keywords
Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression
Sign Up to like & getrecommendations! Published in 2019 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2018.1536985
Abstract: Abstract Context: Prevalence of bronchial asthma massively increases worldwide, while the frequent therapies are still not sufficient. Polydatin, a naturally occurring glycoside, was known as to have anti-inflammatory and anti-oxidant effects. Objective: The current study… read more here.
Keywords: group; asthma rats; expression; polydatin ... See more keywords
The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14320
Abstract: Impaired autophagic degradation of intracellular lipids is causally linked to the development of non‐alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein,… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; autophagic flux; polydatin ... See more keywords
Looking for Responders among Women with Chronic Pelvic Pain Treated with a Comicronized Formulation of Micronized Palmitoylethanolamide and Polydatin
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/8620077
Abstract: Background Palmitoylethanolamide is reported to solve pain and neuroinflammation in different models of chronic and neurodegenerative diseases. Some concerns have been illustrated for cautiously interpreting the available literature on the topic. Specifically, there is a… read more here.
Keywords: pain score; responders among; chronic pelvic; pain ... See more keywords