Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1
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DOI: 10.1002/1873-3468.14625
Abstract: Autoimmune polyendocrine syndrome type I (APS‐1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against tissue proteins and cytokines. We here hypothesised… read more here.
Keywords: syndrome type; cell; autoimmune polyendocrine; polyendocrine syndrome ... See more keywords
Autoimmune polyendocrine syndrome type 4 with systemic lupus erythematosus and anti-phospholipid syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000708
Abstract: Supplemental Digital Content is available in the text read more here.
Keywords: syndrome type; autoimmune polyendocrine; polyendocrine syndrome; syndrome ... See more keywords
Clonal Analysis of Regulatory T Cell Defect in Patients with Autoimmune Polyendocrine Syndrome Type 1 Suggests Intrathymic Impairment
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12586
Abstract: Mutations in the autoimmune regulator gene disrupt thymic T cell development and negative selection, leading to the recessively inherited polyendocrine autoimmune disease autoimmune polyendocrine syndrome type 1 (APS‐1). The patients also have a functional defect… read more here.
Keywords: regulatory cell; syndrome type; autoimmune polyendocrine; polyendocrine syndrome ... See more keywords
Immune checkpoint inhibitor therapy-induced autoimmune polyendocrine syndrome type II and Crohn’s disease: A case report
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DOI: 10.12998/wjcc.v11.i14.3267
Abstract: BACKGROUND The development of immune checkpoint inhibitors (ICIs) has heralded a new era in cancer treatment, enabling the possibility of long-term survival in patients with metastatic disease. Unfortunately, ICIs are increasingly implicated in the development… read more here.
Keywords: autoimmune polyendocrine; polyendocrine syndrome; immune checkpoint; disease ... See more keywords
A novel AIRE mutation leads to autoimmune polyendocrine syndrome type-1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.948350
Abstract: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare inherited monogenic autoimmune disease characterized by the presence of at least two of three following major clinical features: chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency. Mutations in… read more here.
Keywords: syndrome type; autoimmune polyendocrine; polyendocrine syndrome; aire gene ... See more keywords