Enhancement of metabolic flux toward ε-poly-l-lysine biosynthesis by targeted inactivation of concomitant polyene macrolide biosynthesis in Streptomyces albulus.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2019.12.002
Abstract: ε-Poly-l-lysine (ε-PL) produced as a secondary metabolite of Streptomyces albulus has long been used as a natural food preservative in a number of countries, including Japan, the United States, South Korea, and China. To date,… read more here.
Keywords: poly lysine; biosynthesis; production; flux ... See more keywords
Ab Initio and Theoretical Study on Electron Transport through Polyene Junctions in between Carbon Nanotube Leads of Various Cuts
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63363-3
Abstract: In this study we look into the interference effect in multi-thread molecular junctions in between carbon-nanotube (CNT) electrodes of assorted edges. From the tube end into the tube bulk of selected CNTs, we investigate surface… read more here.
Keywords: theoretical study; carbon nanotube; study; junctions carbon ... See more keywords
ZnI2/Zn(OTf)2-TsOH: a versatile combined-acid system for catalytic intramolecular hydrofunctionalization and polyene cyclization.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc07242j
Abstract: A mild and efficient combined-acid system using a zinc(ii) salt [ZnI2 or Zn(OTf)2] and p-toluene sulfonic acid (TsOH) was investigated for catalytic cationic cyclizations, including intramolecular hydrocarboxylation, hydroalkoxylation, hydroamination, hydroamidation, hydroarylation and polyene cyclizations. This… read more here.
Keywords: acid system; zni2 otf; combined acid; tsoh ... See more keywords
P-1086. COT-832, a Novel Polyene Macrolide Antifungal (I): In Vitro Antifungal Activity against Candida, Aspergillus, and Mucor, etc., Hemolytic Activity, and Cytotoxicity
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.1274
Abstract: Abstract Background A novel polyene macrolide antifungal, COT-832 was created by SHIONOGI through structurally modifying Amphotericin B(AmB). Invasive fungal infections are commonly treated with antifungal drugs such as azoles, polyenes, and echinocandins; however, their efficacy… read more here.
Keywords: cot 832; shionogi; polyene; antifungal activity ... See more keywords
New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11030334
Abstract: Glycosylated polyene macrolides include effective antifungal agents, such as pimaricin, nystatin, candicidin, and amphotericin B. For the treatment of systemic mycoses, amphotericin B has been described as a gold-standard antibiotic because of its potent activity… read more here.
Keywords: polyene macrolides; polyene; genome; glycosylated polyene ... See more keywords
The Discovery of Weddellamycin, a Tricyclic Polyene Macrolactam Antibiotic from an Antarctic Deep-Sea-Derived Streptomyces sp. DSS69, by Heterologous Expression
Sign Up to like & getrecommendations! Published in 2024 at "Marine Drugs"
DOI: 10.3390/md22040189
Abstract: Polyene macrolactams are a special group of natural products with great diversity, unique structural features, and a wide range of biological activities. Herein, a cryptic gene cluster for the biosynthesis of putative macrolactams was disclosed… read more here.
Keywords: weddellamycin; polyene; heterologous expression; discovery weddellamycin ... See more keywords