New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining
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DOI: 10.3390/antibiotics11030334
Abstract: Glycosylated polyene macrolides include effective antifungal agents, such as pimaricin, nystatin, candicidin, and amphotericin B. For the treatment of systemic mycoses, amphotericin B has been described as a gold-standard antibiotic because of its potent activity… read more here.
Keywords: polyene macrolides; polyene; genome; glycosylated polyene ... See more keywords
Effect of Post–Polyketide Synthase Modification Groups on Property and Activity of Polyene Macrolides
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12010119
Abstract: The biosynthesis of polyene macrolides, which are natural products produced by soil actinomycetes, have been extensively explored, and recent studies have focused on the effects of post–polyketide synthase (PKS) modifications to polyene macrolides on toxicity,… read more here.
Keywords: modification; polyene macrolides; modification groups; post polyketide ... See more keywords