Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity focused semi-synthesis
Sign Up to like & getrecommendations! Published in 2020 at "Nature chemistry"
DOI: 10.1038/s41557-020-00601-1
Abstract: Polyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. Nevertheless, ionophore… read more here.
Keywords: polyether ionophores; antibacterial selectivity; polyether; synthesis ... See more keywords
Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154708
Abstract: Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis… read more here.
Keywords: evidence metallic; ion homeostasis; polyether ionophores; ionophores potent ... See more keywords