Soluble epoxide hydrolase inhibitory activity of phenolic glycosides from Polygala tenuifolia and in silico approach
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2096-2
Abstract: The goal of this study was to identify soluble epoxide hydrolase (sEH) inhibitors from plants. Our efforts led to the isolation of nine phenolic glycosides 1–9 from the roots of Polygala tenuifolia Willd. The structures… read more here.
Keywords: soluble epoxide; polygala tenuifolia; epoxide hydrolase; phenolic glycosides ... See more keywords
Effects of Magnolia officinalis compatibility with Polygala tenuifolia on mitochondrial metabolism in rats’ liver based on bio-thermodynamics
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-017-6197-4
Abstract: Polygala tenuifolia (Yuanzhi in Chinese) has gastrointestinal toxicity which can be significantly alleviated by Magnolia officinalis (Houpo in Chinese) due to the heat production of mitochondria based on our previous study. In this paper, we… read more here.
Keywords: compatibility; thermodynamics; metabolism; polygala tenuifolia ... See more keywords
Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111650
Abstract: Inspired by the traditional Chinese herbal pair of Polygala tenuifolia-Acori Tatarinowii for treating epilepsy, 33 novel substituted cinnamic α-asaronol esters and analogues were designed by Combination of Traditional Chinese Medicine Molecular Chemistry (CTCMMC) strategy, synthesized… read more here.
Keywords: herbal pair; polygala tenuifolia; acori tatarinowii; chemistry ... See more keywords
Structural characterization and anti-neuroinflammatory activity of a heteropolysaccharide isolated from the rhizomes of Polygala tenuifolia
Sign Up to like & getrecommendations! Published in 2020 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2020.112792
Abstract: Abstract Polygala tenuifolia Willd. is a vital industrial-export plant in Southeast Asia, particularly China. The rhizomes of P. tenuifolia are known for their nootropic and cognition-improving effects. As such, they have been widely used in… read more here.
Keywords: ptp70; polygala tenuifolia; neuroinflammatory activity; anti neuroinflammatory ... See more keywords
Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113764
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Ambroxol elevates glucocerebrosidase (GCase) activity and reduces nigrostriatal alpha-synuclein burden to better ameliorate motor function in Parkinson's disease (PD). Polygala tenuifolia is a potential alternative botanical medicine for the treatment of many nonmotor… read more here.
Keywords: blood brain; polygala tenuifolia; multiple microdialysis; blood ... See more keywords
Sugar easters and xanthones from the roots of Polygala tenuifolia Willd. and their cytoprotective activity.
Sign Up to like & getrecommendations! Published in 2022 at "Fitoterapia"
DOI: 10.2139/ssrn.4112906
Abstract: Six new sugar esters (1-6), named tenuifolisides F-G (1-2) and tenuifolioses W-Z (3-6), together with 16 known compounds (7-22) were isolated from the roots of Polygala tenuifolia. The chemical structures of the new compounds were… read more here.
Keywords: polygala tenuifolia; cytoprotective activity; roots polygala; sugar easters ... See more keywords
Optimization of Ultrasonic-Assisted Extraction of Active Components and Antioxidant Activity from Polygala tenuifolia: A Comparative Study of the Response Surface Methodology and Least Squares Support Vector Machine
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103069
Abstract: Dried roots of Polygala tenuifolia (YuanZhi in Chinese) are widely used in Chinese herbal medicine. These components in YuanZhi have significant anti-oxidation properties owing to high levels of 3,6’-disinapoylsucrose (DISS) and Polygalaxanthone III (PolyIII). In… read more here.
Keywords: antioxidant activity; methodology; polygala tenuifolia; extraction ... See more keywords
Bioactive Compounds from Polygala tenuifolia and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Pro-inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells
Sign Up to like & getrecommendations! Published in 2020 at "Plants"
DOI: 10.3390/plants9091240
Abstract: The roots of Polygala tenuifolia Wild (Polygalaceae), which is among the most important components of traditional Chinese herbal medicine, have been widely used for over 1000 years to treat a variety of diseases. In the… read more here.
Keywords: anti inflammatory; lipopolysaccharide stimulated; production; polygala tenuifolia ... See more keywords
Inhibitory activity of 4-O-benzoyl-3'-O-(O-methylsinapoyl)sucrose from Polygala tenuifolia on Escherichia coli β-glucuronidase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.2108.08004
Abstract: Bacterial β-glucuronidase in the intestine is involved in the conversion of 7-ethyl-10-hydroxycamptochecin glucuronide (derived from irinotecan) to 7-ethyl-10-hydroxycamptothecin, which causes intestinal bleeding and diarrhea (side effects of anti-cancer drugs). Twelve compounds (1-12) from Polygala tenuifolia… read more here.
Keywords: polygala tenuifolia; benzoyl methylsinapoyl; methylsinapoyl sucrose; glucuronidase ... See more keywords