A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits.
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DOI: 10.1016/j.ajhg.2021.03.002
Abstract: The development of polygenic risk scores (PRSs) has proved useful to stratify the general European population into different risk groups. However, PRSs are less accurate in non-European populations due to genetic differences across different populations.… read more here.
Keywords: framework; polygenic; genetic correlation; cross population ... See more keywords