Evidence of Polygenic Adaptation in Sardinia at Height-Associated Loci Ascertained from the Biobank Japan.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.05.014
Abstract: Adult height is one of the earliest putative examples of polygenic adaptation in humans. However, this conclusion was recently challenged because residual uncorrected stratification from large-scale consortium studies was considered responsible for the previously noted… read more here.
Keywords: loci; associated loci; polygenic adaptation; height associated ... See more keywords
Polygenic Adaptation Underlies Evolution of Brain Structures and Behavioral Traits
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.102
Abstract: Abstract Many of the characteristics of psychiatric disorders, including their early age of onset, moderate to high prevalence (i.e., 1% for schizophrenia, >15% for major depression), reduced fecundity, and high heritability have led many to… read more here.
Keywords: adaptation underlies; underlies evolution; selection; brain ... See more keywords
Evidence of Polygenic Adaptation to High Altitude from Tibetan and Sherpa Genomes
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evy233
Abstract: Abstract Although Tibetans and Sherpa present several physiological adjustments evolved to cope with selective pressures imposed by the high-altitude environment, especially hypobaric hypoxia, few selective sweeps at a limited number of hypoxia related genes were… read more here.
Keywords: altitude; high altitude; tibetan sherpa; adaptation high ... See more keywords
Detecting parallel polygenic adaptation to novel evolutionary pressure in wild populations: a case study in Atlantic cod (Gadus morhua)
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0190
Abstract: Populations can adapt to novel selection pressures through dramatic frequency changes in a few genes of large effect or subtle shifts in many genes of small effect. The latter (polygenic adaptation) is expected to be… read more here.
Keywords: gadus morhua; polygenic adaptation; adaptation; atlantic cod ... See more keywords
Signatures of polygenic adaptation associated with climate across the range of a threatened fish species with high genetic connectivity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Ecology"
DOI: 10.1111/mec.14368
Abstract: Adaptive differences across species’ ranges can have important implications for population persistence and conservation management decisions. Despite advances in genomic technologies, detecting adaptive variation in natural populations remains challenging. Key challenges in gene–environment association studies… read more here.
Keywords: signatures polygenic; range; fish species; adaptation ... See more keywords
Detecting the genomic signal of polygenic adaptation and the role of epistasis in evolution
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Ecology"
DOI: 10.1111/mec.14499
Abstract: Over the last decade, the genomic revolution has offered the possibility to generate tremendous amounts of data that contain valuable information on the genetic basis of phenotypic traits, such as those linked to human diseases… read more here.
Keywords: adaptation role; signal polygenic; genomic signal; adaptation ... See more keywords