Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.3171
Abstract: Importance Risk prediction for coronary heart disease (CHD) is a cornerstone of primary prevention strategies. Polygenic risk scores (PRSs) have emerged as a new approach to predict risk in asymptomatic people. Polygenic risk scores for… read more here.
Keywords: risk scores; polygenic risk; prs; risk ... See more keywords
Association of a Polygenic Risk Score With Breast Cancer Among Women Carriers of High- and Moderate-Risk Breast Cancer Genes.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2020.8501
Abstract: Importance To date, few studies have examined the extent to which polygenic single-nucleotide variation (SNV) (formerly single-nucleotide polymorphism) scores modify risk for carriers of pathogenic variants (PVs) in breast cancer susceptibility genes. In previous reports,… read more here.
Keywords: risk; breast cancer; polygenic risk; cancer ... See more keywords
Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.47162
Abstract: Key Points Question Is a polygenic risk score (PRS) derived from European ancestry data associated with Alzheimer disease (AD) dementia risk in non-European populations? Findings In this cohort study of genome data from European and… read more here.
Keywords: disease; alzheimer disease; risk score; polygenic risk ... See more keywords
Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2022.4688
Abstract: Importance Irreversible vision loss from primary open-angle glaucoma (POAG) can be prevented through timely diagnosis and treatment, although definitive diagnosis can be difficult in early-stage disease. As a consequence, large numbers of individuals with suspected… read more here.
Keywords: glaucoma; progression; polygenic risk; risk ... See more keywords
From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.3049
Abstract: Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of individuals to diseases. All individuals have DNA risk variants for all common diseases, but genetic susceptibility differences between people reflect the cumulative burden… read more here.
Keywords: medicine; risk; prs; risk variants ... See more keywords
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.2742
Abstract: This cross-sectional study benchmarks the penetrance of current neuropsychiatric polygenic risk scores in the Veterans Health Administration health care system, and explores associations between polygenic risk scores and broad categories of human disease via phenome-wide… read more here.
Keywords: care system; risk scores; health care; polygenic risk ... See more keywords
Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.4234
Abstract: Importance Predictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are lacking. Longitudinally ascertained medication use may empower studies examining associations between… read more here.
Keywords: prs scz; polygenic risk; ssd taking; individuals ssd ... See more keywords
Brain morphology, autistic traits, and polygenic risk for autism: A population‐based neuroimaging study
Sign Up to like & getrecommendations! Published in 2021 at "Autism Research"
DOI: 10.1002/aur.2576
Abstract: Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to replicate and extend… read more here.
Keywords: autistic traits; autism; polygenic risk; brain ... See more keywords
Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4934
Abstract: Prostate cancer (PCa) screening is not routinely conducted in men aged 55 and younger, although this age group accounts for more than 10% of cases. Polygenic risk scores (PRSs) and patient data applied toward early… read more here.
Keywords: prostate cancer; risk scores; polygenic risk; risk ... See more keywords
Multiethnic polygenic risk scores improve risk prediction in diverse populations
Sign Up to like & getrecommendations! Published in 2017 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22083
Abstract: Methods for genetic risk prediction have been widely investigated in recent years. However, most available training data involves European samples, and it is currently unclear how to accurately predict disease risk in other populations. Previous… read more here.
Keywords: polygenic risk; risk prediction; risk; training data ... See more keywords
Polygenic risk scores outperform machine learning methods in predicting coronary artery disease status
Sign Up to like & getrecommendations! Published in 2020 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22279
Abstract: Coronary artery disease (CAD) is the leading global cause of mortality and has substantial heritability with a polygenic architecture. Recent approaches of risk prediction were based on polygenic risk scores (PRS) not taking possible nonlinear… read more here.
Keywords: risk; cad; coronary artery; polygenic risk ... See more keywords