Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians
Sign Up to like & getrecommendations! Published in 2019 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-019-01040-x
Abstract: A recent study reported a negative association between a putatively functional dopamine (DA) polygenic score, indexing higher levels of DA signaling, and depressive symptoms. We attempted to replicate this association using data from the Duke… read more here.
Keywords: association; depressive symptoms; dopamine polygenic; polygenic score ... See more keywords
Polygenic Score for Alzheimer Disease and cognition: The mediating role of personality.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2018.10.015
Abstract: Alzheimer's disease (AD) polygenic risk score (PGS) is associated with lower cognitive functioning even among older individuals without dementia. We tested the hypothesis that personality traits mediate the association between AD genetic risk and cognitive… read more here.
Keywords: alzheimer disease; polygenic score; personality; score ... See more keywords
Polygenic score for sleep duration. Association with cognition.
Sign Up to like & getrecommendations! Published in 2020 at "Sleep medicine"
DOI: 10.1016/j.sleep.2020.07.001
Abstract: STUDY OBJECTIVES Age-related changes in sleep include a reduction in total sleep time and a greater incidence of sleep disorders, and are also an integral part of neurodegenerations. In the present study, we aimed to:… read more here.
Keywords: sleep duration; polygenic score; duration; association ... See more keywords
Genomic prediction of cognitive traits in childhood and adolescence
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0394-4
Abstract: Recent advances in genomics are producing powerful DNA predictors of complex traits, especially cognitive abilities. Here, we leveraged summary statistics from the most recent genome-wide association studies of intelligence and educational attainment, with highly genetically… read more here.
Keywords: genomic prediction; prediction cognitive; cognitive traits; polygenic score ... See more keywords
The Role of Polygenic Score and Cognitive Activity in Cognitive Functioning among Older Adults.
Sign Up to like & getrecommendations! Published in 2020 at "The Gerontologist"
DOI: 10.1093/geront/gnaa073
Abstract: BACKGROUND AND OBJECTIVES This study explored whether the intensity of cognitive activities could moderate the relationship between a genetic predisposition for developing Alzheimer's disease (AD) and cognitive functioning among older adults in the U.S. Further,… read more here.
Keywords: polygenic score; functioning among; among older; older adults ... See more keywords
Associations between an educational attainment polygenic score with educational attainment in an African American sample
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1111/gbb.12558
Abstract: Polygenic propensity for educational attainment has been associated with higher education attendance, academic achievement and criminal offending in predominantly European samples; however, less is known about whether this polygenic propensity is associated with these outcomes… read more here.
Keywords: attainment polygenic; educational attainment; polygenic score; education ... See more keywords
Improved Genomic Prediction of Staphylococcus epidermidis Isolation Sources with a Novel Polygenic Score
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01412-22
Abstract: Staphylococcus epidermidis infections can be challenging to diagnose due to the species frequent contamination of clinical specimens and indolent course of infection. Nevertheless, S. epidermidis is the major cause of late-onset sepsis among premature infants… read more here.
Keywords: polygenic score; staphylococcus epidermidis; infection; isolation sources ... See more keywords
Evaluation of polygenic prediction methodology within a reference-standardized framework
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009021
Abstract: The predictive utility of polygenic scores is increasing, and many polygenic scoring methods are available, but it is unclear which method performs best. This study evaluates the predictive utility of polygenic scoring methods within a… read more here.
Keywords: methodology; polygenic score; reference; standardized framework ... See more keywords
Genotype imputation and polygenic score estimation in northwestern Russian population
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269434
Abstract: Numerous studies demonstrated the lack of transferability of polygenic score (PGS) models across populations and the problem arising from unequal presentation of ancestries across genetic studies. However, even within European ancestry there are ethnic groups… read more here.
Keywords: polygenic score; imputation; genotype imputation; imputation polygenic ... See more keywords
How can we address the uncertainties regarding the potential clinical utility of polygenic score-based tests?
Sign Up to like & getrecommendations! Published in 2022 at "Personalized medicine"
DOI: 10.2217/pme-2021-0148
Abstract: As common low penetrance variants associated with diseases are uncovered, attempts continue to be made to harness this knowledge for improving healthcare. Polygenic scores have been developed as the mechanism by which knowledge of common… read more here.
Keywords: polygenic score; based tests; utility polygenic; score based ... See more keywords
Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.650220
Abstract: The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health. Recent epidemiological and genetics studies have revealed the polygenic… read more here.
Keywords: score models; alzheimer disease; research clinical; polygenic score ... See more keywords