Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.48585
Abstract: Key Points Question Are genome-wide polygenic scores for specific psychiatric and common traits associated with high risk of suicide among preadolescent youths? Findings In this cohort study of 11 869 preadolescent youths in the US, multiple… read more here.
Keywords: preadolescent youths; wide polygenic; risk suicide; polygenic scores ... See more keywords
No support for the hereditarian hypothesis of the Black-White achievement gap using polygenic scores and tests for divergent selection.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of physical anthropology"
DOI: 10.1002/ajpa.24216
Abstract: OBJECTIVES Debate about the cause of IQ score gaps between Black and White populations has persisted within genetics, anthropology, and psychology. Recently, authors claimed polygenic scores provide evidence that a significant portion of differences in… read more here.
Keywords: black white; anthropology; polygenic scores; selection ... See more keywords
Structural architecture and brain network efficiency link polygenic scores to intelligence
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26286
Abstract: Intelligence is highly heritable. Genome-wide association studies (GWAS) have shown that thousands of alleles contribute to variation in intelligence with small effect sizes. Polygenic scores (PGS), which combine these effects into one genetic summary measure,… read more here.
Keywords: network efficiency; polygenic scores; intelligence; brain ... See more keywords
The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial
Sign Up to like & getrecommendations! Published in 2019 at "Prevention Science"
DOI: 10.1007/s11121-019-01024-2
Abstract: Alcohol problems are influenced by both genetic and environmental factors. Evidence from twin models and measured gene-environment interaction studies has demonstrated that the importance of genetic influences changes as a function of the environment. Research… read more here.
Keywords: intervention; polygenic scores; family; alcohol dependence ... See more keywords
Polygenic Scores for Cognitive Abilities and Their Association with Different Aspects of General Intelligence—A Deep Phenotyping Approach
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02398-7
Abstract: Intelligence is a highly polygenic trait and genome-wide association studies (GWAS) have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As… read more here.
Keywords: intelligence; polygenic scores; scores cognitive; pgs ... See more keywords
Polygenic Scores: a public health hazard?
Sign Up to like & getrecommendations! Published in 2019 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2019.08.004
Abstract: Abstract I argue here that polygenic scores are a public health hazard because the underlying methodology, genome wide association, from which they are derived, incorrectly assumes that the information encoded in the genomic DNA sequence… read more here.
Keywords: health hazard; public health; scores public; polygenic scores ... See more keywords
Polygenic scores mediate the Jewish phenotypic advantage in educational attainment and cognitive ability compared with Catholics and Lutherans.
Sign Up to like & getrecommendations! Published in 2019 at "Evolutionary Behavioral Sciences"
DOI: 10.1037/ebs0000158
Abstract: A newly released multivariate polygenic score for educational attainment, cognitive ability, and self-rated mathematical ability in the Wisconsin Longitudinal Study was examined as a mediator of the group difference between Jews (n = 53) and… read more here.
Keywords: ability; cognitive ability; attainment cognitive; educational attainment ... See more keywords
Three models for the regulation of polygenic scores in reproduction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2020-106588
Abstract: The past few years have brought significant breakthroughs in understanding human genetics. This knowledge has been used to develop ‘polygenic scores’ (or ‘polygenic risk scores’) which provide probabilistic information about the development of polygenic conditions… read more here.
Keywords: embryo selection; polygenic scores; genetics; disease ... See more keywords
Advances and Applications of Polygenic Scores for Coronary Artery Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of medicine"
DOI: 10.1146/annurev-med-042921-112629
Abstract: Polygenic scores quantify inherited risk by integrating information from many common sites of DNA variation into a single number. Rapid increases in the scale of genetic association studies and new statistical algorithms have enabled development… read more here.
Keywords: polygenic scores; artery disease; risk; coronary artery ... See more keywords
Polygenic Scores for Plasticity: A New Tool for Studying Gene-Environment Interplay.
Sign Up to like & getrecommendations! Published in 2022 at "Demography"
DOI: 10.1215/00703370-9957418
Abstract: Fertility, health, education, and other outcomes of interest to demographers are the product of an individual's genetic makeup and their social environment. Yet, gene × environment (G×E) research deploys a limited toolkit on the genetic… read more here.
Keywords: environment interplay; polygenic scores; environment; gene environment ... See more keywords
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes Care"
DOI: 10.2337/dc21-1395
Abstract: OBJECTIVE Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 diabetes-related… read more here.
Keywords: disease outcomes; type diabetes; partitioned polygenic; polygenic scores ... See more keywords