Quantification of eight active ingredients in crude and processed radix polygoni multiflori applying miniaturized matrix solid-phase dispersion microextraction followed by UHPLC.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201800342
Abstract: A rapid, efficient, and green sample preparation method has been developed to extract eight active ingredients (gallic acid, catechins, epicatechin, polydatin, 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside, resveratrol, emodin, and physcion) in radix polygoni multiflori by miniaturized matrix solid-phase dispersion… read more here.
Keywords: miniaturized matrix; matrix solid; solid phase; polygoni multiflori ... See more keywords
Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112577
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) that is used after processing are two well-known traditional Chinese medicines. PMRP is traditionally reported to have lipid-reducing activity as recorded in Chinese… read more here.
Keywords: pmrwe pmrpwe; polygoni multiflori; multiflori radix;
Comprehensive analysis of Polygoni Multiflori Radix of different geographical origins using ultra-high-performance liquid chromatography fingerprints and multivariate chemometric methods.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of food and drug analysis"
DOI: 10.1016/j.jfda.2016.11.009
Abstract: Polygoni Multiflori Radix (PMR) is increasingly being used not just as a traditional herbal medicine but also as a popular functional food. In this study, multivariate chemometric methods and mass spectrometry were combined to analyze… read more here.
Keywords: chemometric methods; analysis; polygoni multiflori; multiflori radix ... See more keywords
Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury.
Sign Up to like & getrecommendations! Published in 2017 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(17)30067-5
Abstract: Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones… read more here.
Keywords: absorption; emodin; metabolism emodin; polygoni multiflori ... See more keywords
Hematopoietic effect of small molecular fraction of Polygoni multiflori Radix Praeparata in cyclophosphamide-induced anemia mice.
Sign Up to like & getrecommendations! Published in 2019 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(19)30075-5
Abstract: The aim of this study is to investigate the protective effects of a small molecular fraction (SMF) of Polygoni multiflori Radix Praeparata (PMRP) in a cyclophosphamide (CTX) induced anemia mouse model. Small molecular fraction of… read more here.
Keywords: molecular fraction; induced anemia; polygoni multiflori; small molecular ... See more keywords
Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2020/4508374
Abstract: Radix Polygoni Multiflori (RPM) has been widely used to treat various diseases in Asian countries for many centuries. Although, stilbenes and anthraquinones, two major components of RPM, show various bioactive effects, it has been speculated… read more here.
Keywords: simultaneous determination; rat plasma; plasma; polygoni multiflori ... See more keywords
Polygoni Multiflori Radix Preparat Delays Skin Aging by Inducing Mitophagy
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/5847153
Abstract: Background As the skin is the largest organ of the human body, it is aging inevitably and produces cosmetic and psychological problems, and even disease. Therefore, the molecular mechanisms related to the prevention of skin… read more here.
Keywords: aging inducing; radix preparat; skin aging; polygoni multiflori ... See more keywords
Hepatotoxic metabolites in Polygoni Multiflori Radix— Comparative toxicology in mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1007284
Abstract: Polygoni Multiflori Radix (PM) and Rhei radix et rhizoma (rhubarb) contain similar hepatocyte-toxic anthraquinones such as emodin (major free anthraquinone in PM), physcion and their glycosides. In clinical practice, PM hepatotoxicity has been widely reported,… read more here.
Keywords: toxicology; multiflori radix; tsg; group ... See more keywords
Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.827668
Abstract: Although progress has been achieved in the pharmacological activity and toxicity of Radix Polygoni Multiflori (RPM), the chemical basis of its toxicity is still unclear. Here, we performed a multicompound pharmacokinetic analysis and investigated the… read more here.
Keywords: radix polygoni; excretion characteristics; distribution excretion; tissue distribution ... See more keywords
Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.868327
Abstract: Background: Reynoutria multiflora (Thunb.) Moldenke (PM) is a widely-used medicinal plant in China, whose root and stem are included in the Chinese Pharmacopoeia as Polygoni Multiflori Radix (RPM), Polygoni Multiflori Radix Preparata (PMP), and Polygoni… read more here.
Keywords: potential risks; liver injury; rpm pmp; induced liver ... See more keywords
Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.878817
Abstract: Polygoni Multiflori Radix (PMR), the dried root of Polygonum Multiflorum Thunb., has been widely used as traditional Chinese medicines in clinical practice for centuries. However, the frequently reported hepatotoxic adverse effects hindered its safe use… read more here.
Keywords: day; day treatment; physcion; pmr ... See more keywords