Characterization of the chemical constituents and metabolic profile of Polygonum cuspidatum Sieb. et Zucc. in rat plasma, urine, and feces by ultra-high performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200522
Abstract: Polygonum cuspidatum Sieb. et Zucc. is a traditional and popular Chinese medicine with a wide spectrum of pharmacological effects such as anti-bacterial, anti-inflammatory, and anti-tumor activities together with other health effects like lowering lipids, preventing… read more here.
Keywords: cuspidatum; metabolic profile; polygonum cuspidatum; chemical constituents ... See more keywords
Bioactive phenylpropanoid esters of sucrose and anthraquinones from Polygonum cuspidatum.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104673
Abstract: Four new compounds including two new phenylpropanoid esters of sucrose, polygonusucroside A (1) and B (2); two new anthraquinones, 8-O-β-d-(6'-galloyl)-glucopyranoside (3) and polyanthraquinoside A (4), together with six known compounds were isolated from Polygonum cuspidatum.… read more here.
Keywords: bioactive phenylpropanoid; polygonum cuspidatum; sucrose anthraquinones; phenylpropanoid esters ... See more keywords
Potential of Polygonum cuspidatum Root as an Antidiabetic Food: Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-HRMS and NMR for Identification of Antidiabetic Constituents.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b01353
Abstract: The worldwide increasing incidence of type 2 diabetes has fueled an intensified search for food and herbal remedies with preventive and/or therapeutic properties. Polygonum cuspidatum Siebold & Zucc. (Polygonaceae) is used as a functional food… read more here.
Keywords: high resolution; polygonum cuspidatum; dual high; ptp1b ... See more keywords
Discovery of the Endophytic Fungi from Polygonum cuspidatum and Biotransformation of Resveratrol to Pterostillbene by the Endophyte Penicillium sp. F5
Sign Up to like & getrecommendations! Published in 2020 at "Applied Biochemistry and Microbiology"
DOI: 10.1134/s0003683820030163
Abstract: In this study, fungal endophytes were screened from samples of Polygonum cuspidatum and 24 endophytes were obtained. The fungal endophytes were allocated to 6 orders and 9 genera by phylogenetic analysis. Based on the ability… read more here.
Keywords: polygonum cuspidatum; penicillium; biotransformation resveratrol; fungal endophytes ... See more keywords
Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/3830671
Abstract: Polygonum cuspidatum (PC) has been reported to exert a potent antihyperlipidemic effect. However, its mechanisms of action and active ingredients remain elusive and require further research. In this study, we first conducted in vivo experiments… read more here.
Keywords: cuspidatum extract; polygonum cuspidatum; foxo3; signaling pathway ... See more keywords
Investigation of the Potential Key Genes and the Multitarget Mechanisms of Polygonum cuspidatum against Heart Failure Based on Network Pharmacology and Experimental Validation
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/7784021
Abstract: In this study, systematic pharmacology and bioinformatic approaches were employed to identify the potential targets of Polygonum cuspidatum (PC) for treating heart failure (HF). The active ingredients of PC were screened by using the TCMSP… read more here.
Keywords: heart failure; pharmacology; key genes; polygonum cuspidatum ... See more keywords
Luteolin Isolated from Polygonum cuspidatum Is a Potential Compound against Nasopharyngeal Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/9740066
Abstract: Introduction To reveal the mechanisms by which luteolin, the major bioactive component of the Traditional Chinese Medicine (TCM) Polygonum cuspidatum, inhibits proliferation and promotes apoptosis in nasopharyngeal carcinoma (NPC) CNE2 cells. Methods Based on the… read more here.
Keywords: nasopharyngeal carcinoma; cell; polygonum cuspidatum; luteolin ... See more keywords
The study of ultrasound-assisted extraction of flavonoids from Polygonum cuspidatum Sieb. et Zucc.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Materials Research"
DOI: 10.1557/jmr.2019.144
Abstract: read more here.
Keywords: ultrasound assisted; polygonum cuspidatum; study ultrasound; assisted extraction ... See more keywords
The possibility of Polygonum cuspidatum Against Osteoarthritis Based on Network Pharmacology and Molecular Docking.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230403114131
Abstract: BACKGROUND Polygonum cuspidatum（PC）, a widely used Chinese herbal medicine (CHM), plays an important role in treating various diseases including osteoarthritis (OA). Yet, the multicomponent and multitarget characteristics of PC make deciphering the pharmacological mechanisms difficult.… read more here.
Keywords: molecular docking; network; pharmacology; polygonum cuspidatum ... See more keywords
Root Endophytic Fungi Regulate Changes in Sugar and Medicinal Compositions of Polygonum cuspidatum
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.818909
Abstract: Polygonum cuspidatum Sieb. et Zucc is an important industrial crop because it contains a large amount of medicinal secondary metabolites (such as polydatin, resveratrol, chrysophanol, and emodin). However, it is unclear whether root endophytic fungi… read more here.
Keywords: root; polygonum cuspidatum; root endophytic; secondary metabolites ... See more keywords
PcWRKY11, an II-d WRKY Transcription Factor from Polygonum cuspidatum, Enhances Salt Tolerance in Transgenic Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084357
Abstract: Being an invasive plant, Polygonum cuspidatum is highly resilient and can survive in unfavorable environments for long periods; however, its molecular mechanisms associated with such environmental resistance are largely unknown. In this study, a WRKY… read more here.
Keywords: thaliana; pcwrky11; polygonum cuspidatum; cuspidatum ... See more keywords