LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "polyketide" as a keyword



Aromatic Polyketide GTRI‐02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2)

Sign Up to like & get
recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700107

Abstract: The biosynthesis of aromatic polyketides derived from type II polyketide synthases (PKSs) is complex, and it is not uncommon that highly similar gene clusters give rise to diverse structural architectures. The act biosynthetic gene cluster (BGC)… read more here.

Keywords: polyketide; act; gtri; gene cluster ... See more keywords
Photo from archive.org

Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.

Sign Up to like & get
recommendations! Published in 2018 at "Journal of structural biology"

DOI: 10.1016/j.jsb.2018.04.001

Abstract: Ketoreductase (KR) domains of modular polyketide synthases (PKSs) control the stereochemistry of C2 methyl and C3 hydroxyl substituents of polyketide intermediates. To understand the molecular basis of stereocontrol exerted by KRs, the crystal structure of… read more here.

Keywords: polyketide; structures ketoreductase; bound structures; substrate bound ... See more keywords
Photo by sxy_selia from unsplash

Clicking into Place: Interfacing Terminal Alkyne Biosynthesis with Polyketide Synthases.

Sign Up to like & get
recommendations! Published in 2020 at "Trends in biotechnology"

DOI: 10.1016/j.tibtech.2020.04.001

Abstract: Engineering polyketide biosynthesis to enable the production of diverse chemical structures is a major challenge at present. Utilising an established biosynthetic cassette for terminal alkyne production, Porterfield et al. applied docking domain and site-directed mutagenesis… read more here.

Keywords: clicking place; polyketide; biosynthesis; place interfacing ... See more keywords

Tailoring of Prematurely Released Polyketide Intermediates in Piericidin Biosynthesis.

Sign Up to like & get
recommendations! Published in 2025 at "Journal of natural products"

DOI: 10.1021/acs.jnatprod.5c00609

Abstract: Piericidins make up a group of microbial-derived polyketide natural products with a wide variety of biological activities. Their biosynthetic gene clusters (BGCs) have been identified in several strains of Streptomyces. In Streptomyces pactum, the piericidin… read more here.

Keywords: tailoring prematurely; prematurely released; polyketide; released polyketide ... See more keywords

Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01.

Sign Up to like & get
recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c02978

Abstract: Aspertaichunol A (1), a polyketide with a novel scaffold, was isolated from the medicinal insect (Periplaneta americana)-derived endophytic Aspergillus taichungensis SMU01. Its structure was assigned on the basis of spectroscopic data and quantum chemical computational… read more here.

Keywords: endophytic aspergillus; taichungensis smu01; derived endophytic; polyketide ... See more keywords

Directed Evolution of a Modular Polyketide Synthase Thioesterase for Generation of a Hybrid Macrocyclic Ring System.

Sign Up to like & get
recommendations! Published in 2025 at "ACS catalysis"

DOI: 10.1021/acscatal.4c07922

Abstract: Modular type I polyketide synthases (PKSs) comprise a family of enzymes that synthesize a diverse class of natural products with medicinal applications. The biochemical features of these systems include the extension and processing of polyketide… read more here.

Keywords: evolution; modular polyketide; evolution modular; polyketide ... See more keywords

Complementary Genomic, Bioinformatics and Chemical Approaches Facilitate the Absolute Structure Assignment of Ionostatin, a Linear Polyketide from a Rare Marine-Derived Actinomycete.

Sign Up to like & get
recommendations! Published in 2020 at "ACS chemical biology"

DOI: 10.1021/acschembio.0c00526

Abstract: A new linear type 1 polyketide, ionostatin (1) has been fully defined using a combined genomic and bioinformatics approach coupled with confirmatory chemical analyses. The 41 carbon-containing polyether is the product of the 101 kbp… read more here.

Keywords: polyketide; genomic bioinformatics; ionostatin; bioinformatics chemical ... See more keywords
Photo by bermixstudio from unsplash

Structural Basis of Polyketide Synthase O-Methylation.

Sign Up to like & get
recommendations! Published in 2018 at "ACS chemical biology"

DOI: 10.1021/acschembio.8b00687

Abstract: Modular type I polyketide synthases (PKSs) produce some of the most chemically complex metabolites in nature through a series of multienzyme modules. Each module contains a variety of catalytic domains to selectively tailor the growing… read more here.

Keywords: polyketide; structural basis; basis polyketide; hydroxyl ... See more keywords

Heterologous Biosynthesis of Type II Polyketide Products Using E. coli.

Sign Up to like & get
recommendations! Published in 2019 at "ACS chemical biology"

DOI: 10.1021/acschembio.9b00827

Abstract: The heterologous biosynthesis of complex natural products has enabled access to polyketide, nonribosomal peptide, isoprenoid, and other compounds with wide-spanning societal value. Though several surrogate host systems exist, Escherichia coli is often a preferred choice… read more here.

Keywords: polyketide; type polyketide; biology; heterologous biosynthesis ... See more keywords

Direct Utilization of Peroxisomal Acetyl-CoA for the Synthesis of Polyketide Compounds in Saccharomyces cerevisiae.

Sign Up to like & get
recommendations! Published in 2023 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.2c00678

Abstract: Polyketides are a class of natural products with many applications but are mainly appealing as pharmaceuticals. Heterologous production of polyketides in the yeast Saccharomyces cerevisiae has been widely explored because of the many merits of… read more here.

Keywords: acetyl coa; synthesis; polyketide; coa ... See more keywords

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

Sign Up to like & get
recommendations! Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b02875

Abstract: Polyketide synthases (PKSs) represent a powerful catalytic platform capable of effecting multiple carbon-carbon bond forming reactions and oxidation state adjustments. We explored the functionality of two terminal PKS modules that produce the 16-membered tylosin macrocycle,… read more here.

Keywords: polyketide; late stage; tylactone; total synthesis ... See more keywords