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   Articles with "polyketide" as a keyword



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Aromatic Polyketide GTRI‐02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2)

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700107

Abstract: The biosynthesis of aromatic polyketides derived from type II polyketide synthases (PKSs) is complex, and it is not uncommon that highly similar gene clusters give rise to diverse structural architectures. The act biosynthetic gene cluster (BGC)… read more here.

Keywords: polyketide; act; gtri; gene cluster ... See more keywords
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Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.

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recommendations! Published in 2018 at "Journal of structural biology"

DOI: 10.1016/j.jsb.2018.04.001

Abstract: Ketoreductase (KR) domains of modular polyketide synthases (PKSs) control the stereochemistry of C2 methyl and C3 hydroxyl substituents of polyketide intermediates. To understand the molecular basis of stereocontrol exerted by KRs, the crystal structure of… read more here.

Keywords: polyketide; structures ketoreductase; bound structures; substrate bound ... See more keywords
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Clicking into Place: Interfacing Terminal Alkyne Biosynthesis with Polyketide Synthases.

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recommendations! Published in 2020 at "Trends in biotechnology"

DOI: 10.1016/j.tibtech.2020.04.001

Abstract: Engineering polyketide biosynthesis to enable the production of diverse chemical structures is a major challenge at present. Utilising an established biosynthetic cassette for terminal alkyne production, Porterfield et al. applied docking domain and site-directed mutagenesis… read more here.

Keywords: clicking place; polyketide; biosynthesis; place interfacing ... See more keywords
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Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c02978

Abstract: Aspertaichunol A (1), a polyketide with a novel scaffold, was isolated from the medicinal insect (Periplaneta americana)-derived endophytic Aspergillus taichungensis SMU01. Its structure was assigned on the basis of spectroscopic data and quantum chemical computational… read more here.

Keywords: endophytic aspergillus; taichungensis smu01; derived endophytic; polyketide ... See more keywords
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Complementary Genomic, Bioinformatics and Chemical Approaches Facilitate the Absolute Structure Assignment of Ionostatin, a Linear Polyketide from a Rare Marine-Derived Actinomycete.

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recommendations! Published in 2020 at "ACS chemical biology"

DOI: 10.1021/acschembio.0c00526

Abstract: A new linear type 1 polyketide, ionostatin (1) has been fully defined using a combined genomic and bioinformatics approach coupled with confirmatory chemical analyses. The 41 carbon-containing polyether is the product of the 101 kbp… read more here.

Keywords: polyketide; genomic bioinformatics; ionostatin; bioinformatics chemical ... See more keywords
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Structural Basis of Polyketide Synthase O-Methylation.

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recommendations! Published in 2018 at "ACS chemical biology"

DOI: 10.1021/acschembio.8b00687

Abstract: Modular type I polyketide synthases (PKSs) produce some of the most chemically complex metabolites in nature through a series of multienzyme modules. Each module contains a variety of catalytic domains to selectively tailor the growing… read more here.

Keywords: polyketide; structural basis; basis polyketide; hydroxyl ... See more keywords
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Heterologous Biosynthesis of Type II Polyketide Products Using E. coli.

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recommendations! Published in 2019 at "ACS chemical biology"

DOI: 10.1021/acschembio.9b00827

Abstract: The heterologous biosynthesis of complex natural products has enabled access to polyketide, nonribosomal peptide, isoprenoid, and other compounds with wide-spanning societal value. Though several surrogate host systems exist, Escherichia coli is often a preferred choice… read more here.

Keywords: polyketide; type polyketide; biology; heterologous biosynthesis ... See more keywords
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Direct Utilization of Peroxisomal Acetyl-CoA for the Synthesis of Polyketide Compounds in Saccharomyces cerevisiae.

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recommendations! Published in 2023 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.2c00678

Abstract: Polyketides are a class of natural products with many applications but are mainly appealing as pharmaceuticals. Heterologous production of polyketides in the yeast Saccharomyces cerevisiae has been widely explored because of the many merits of… read more here.

Keywords: acetyl coa; synthesis; polyketide; coa ... See more keywords
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Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

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recommendations! Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b02875

Abstract: Polyketide synthases (PKSs) represent a powerful catalytic platform capable of effecting multiple carbon-carbon bond forming reactions and oxidation state adjustments. We explored the functionality of two terminal PKS modules that produce the 16-membered tylosin macrocycle,… read more here.

Keywords: polyketide; late stage; tylactone; total synthesis ... See more keywords
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Dissecting the biosynthesis of the polyketide alkaloid lydicamycin using a complex metabolic network

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recommendations! Published in 2023 at "New Journal of Chemistry"

DOI: 10.1039/d3nj01124k

Abstract: Microorganisms produce a great number of therapeutically interesting and structurally diverse natural products through modular biosynthetic assembly lines, i.e., type I polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs). Lydicamycins... read more here.

Keywords: biosynthesis polyketide; dissecting biosynthesis; lydicamycin using; polyketide ... See more keywords
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ClusterCAD 2.0: an updated computational platform for chimeric type I polyketide synthase and nonribosomal peptide synthetase design

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1075

Abstract: Abstract Megasynthase enzymes such as type I modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) play a central role in microbial chemical warfare because they can evolve rapidly by shuffling parts (catalytic domains) to… read more here.

Keywords: pks nrps; clustercad updated; design; polyketide ... See more keywords