Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation.
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DOI: 10.1016/j.biotechadv.2020.107550
Abstract: Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as glycosides, in which sugar residues act as a decisive factor in their… read more here.
Keywords: polyketide antibiotics; terpenoids polyketide; engineering glycosylation; glycosylation ... See more keywords
Engineering the Erythromycin-Producing Strain Saccharopolyspora erythraea HOE107 for the Heterologous Production of Polyketide Antibiotics
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DOI: 10.3389/fmicb.2020.593217
Abstract: Bacteria of the genus Saccharopolyspora produce important polyketide antibiotics, including erythromycin A (Sac. erythraea) and spinosad (Sac. spinosa). We herein report the development of an industrial erythromycin-producing strain, Sac. erythraea HOE107, into a host for… read more here.
Keywords: polyketide antibiotics; production; sac erythraea; erythraea ... See more keywords