Unique Initiation and Termination Mechanisms Involved in the Biosynthesis of a Hybrid Polyketide-Nonribosomal Peptide Lyngbyapeptin B Produced by the Marine Cyanobacterium Moorena bouillonii
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DOI: 10.1021/acschembio.3c00011
Abstract: Lyngbyapeptin B is a hybrid polyketide-nonribosomal peptide isolated from particular marine cyanobacteria. In this report, we carried out genome sequence analysis of a producer cyanobacterium Moorena bouillonii to understand the biosynthetic mechanisms that generate the… read more here.
Keywords: hybrid polyketide; polyketide nonribosomal; cyanobacterium moorena; moorena bouillonii ... See more keywords
Heterologous- and engineered- biosynthesis of nematocidal polyketide-nonribosomal peptide hybrid macrolactone from extreme thermophilic fungi.
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DOI: 10.1021/jacs.9b11410
Abstract: Fungal polyketide-nonribosomal peptide (PK-NRP) hybrid macrolactones are a growing family of natural products with biomedical and agricultural activities. One of the most important families is the thermolides, which are produced by extreme thermophilic fungi and… read more here.
Keywords: thermophilic fungi; extreme thermophilic; heterologous engineered; nonribosomal peptide ... See more keywords