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   Articles with "polyketide nonribosomal" as a keyword



Unique Initiation and Termination Mechanisms Involved in the Biosynthesis of a Hybrid Polyketide-Nonribosomal Peptide Lyngbyapeptin B Produced by the Marine Cyanobacterium Moorena bouillonii

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recommendations! Published in 2023 at "ACS Chemical Biology"

DOI: 10.1021/acschembio.3c00011

Abstract: Lyngbyapeptin B is a hybrid polyketide-nonribosomal peptide isolated from particular marine cyanobacteria. In this report, we carried out genome sequence analysis of a producer cyanobacterium Moorena bouillonii to understand the biosynthetic mechanisms that generate the… read more here.

Keywords: hybrid polyketide; polyketide nonribosomal; cyanobacterium moorena; moorena bouillonii ... See more keywords

Two Flavoenzymes Convert Fungal Polyketide-Nonribosomal Peptide to cis-2-Butene-1,4-dial-Type Carcinogen via Olefin Dihydroxylation and C-C Bond Cleavage.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c11221

Abstract: Postmodification steps by multiple oxidation enzymes are an effective strategy for converting the polyketide-nonribosomal peptide (PK-NRP) core backbone to structurally distinctive natural products, where decoration steps occurring on conjugated polyenes (olefin ≥3) of the PK-NRP… read more here.

Keywords: polyketide nonribosomal; butene dial; type; two flavoenzymes ... See more keywords

Heterologous- and engineered- biosynthesis of nematocidal polyketide-nonribosomal peptide hybrid macrolactone from extreme thermophilic fungi.

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recommendations! Published in 2020 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.9b11410

Abstract: Fungal polyketide-nonribosomal peptide (PK-NRP) hybrid macrolactones are a growing family of natural products with biomedical and agricultural activities. One of the most important families is the thermolides, which are produced by extreme thermophilic fungi and… read more here.

Keywords: thermophilic fungi; extreme thermophilic; heterologous engineered; nonribosomal peptide ... See more keywords