Studying a Bottleneck of Multimodular Polyketide Synthase Processing: the Polyketide Structure-Dependent Performance of Ketoreductase Domains.
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DOI: 10.1021/acschembio.2c00047
Abstract: Ketoreductases (KRs) are canonical domains of type I polyketide synthases (PKSs). They stereoselectively reduce ACP-bound β-ketothioester intermediates and are responsible for a large part of the stereocenters in reduced polyketides. Albeit essential for the understanding… read more here.
Keywords: dependent performance; structure; polyketide structure; studying bottleneck ... See more keywords