A Type III Polyketide Synthase Specific for Sporulating Negativicutes is Responsible for Alkylpyrone Biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200431
Abstract: Genomic analyses indicate that anaerobic bacteria represent a neglected source of natural products. Whereas a limited number of polyketides have been reported from anaerobes, products of type III polyketide synthases (PKSs) have remained unknown. We… read more here.
Keywords: type iii; specific sporulating; polyketide synthase; type ... See more keywords
Insights into an alternative benzofuran binding mode and novel scaffolds of polyketide synthase 13 inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4010-y
Abstract: AbstractSmall molecules targeting biosynthesis of mycolic acids in the tuberculosis causing bacterium carry high potential for anti-tuberculosis drug discovery. Hitherto, benzofuran containing molecules were identified to target the thioesterase domain of polyketide synthase 13 (Pks13),… read more here.
Keywords: methodology; screening; polyketide synthase; binding mode ... See more keywords
Structural Insights into Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00305
Abstract: Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA) and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis.… read more here.
Keywords: structural insights; polyketide synthase; specificity acyltransferases; insights substrate ... See more keywords
Polyketide Synthase-Terpenoid Synthase Hybrid Pathway Regulation of Trap Formation through Ammonia Metabolism Controls Soil Colonization of Predominant Nematode-Trapping Fungus.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c00771
Abstract: Polyketide synthase-terpenoid synthase (PKS-TPS) hybrid pathways for biosynthesis of unique sesquiterpenyl epoxy-cyclohexenoids (SECs) have been found to be widely distributed in plant pathogenic fungi. However, the natural and ecological functions of these pathways and their… read more here.
Keywords: synthase; polyketide synthase; colonization; hybrid pathway ... See more keywords
Formation of 3-Orsellinoxypropanoic Acid in Penicillum crustosum is Catalyzed by a Bifunctional Nonreducing Polyketide Synthase.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04189
Abstract: The heterologous expression of a nonreducing polyketide synthase gene oesA from Penicillium crustosum led to the identification of orsellinoylpropanoic acid (1). Domain deletion and recombination proved that OesA catalyzes not only the formation of orsellinic… read more here.
Keywords: crustosum; polyketide synthase; acid; nonreducing polyketide ... See more keywords
Aspcandine: A Pyrrolobenzazepine Alkaloid Synthesized by a Fungal Nonribosomal Peptide Synthetase-Polyketide Synthase Hybrid.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01918
Abstract: Characterization of an orphan biosynthetic gene cluster found in the fungus Aspergillus candidus CBS 102.13 resulted in the discovery of a pyrrolobenzazepine alkaloid, aspcandine (1). The unique molecular scaffold of 1 is synthesized by the… read more here.
Keywords: peptide synthetase; pyrrolobenzazepine alkaloid; synthetase polyketide; polyketide synthase ... See more keywords
Biosynthesis of Tetronates by a Nonribosomal Peptide Synthetase-Polyketide Synthase System.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00103
Abstract: A cryptic tetronate biosynthetic pathway was identified in Kitasatospora niigatensis DSM 44781 via heterologous expression. Distinct from the currently known biosynthetic pathways, this system utilizes a partially functional nonribosomal peptide synthetase and a broadly selective… read more here.
Keywords: nonribosomal peptide; peptide synthetase; system; polyketide synthase ... See more keywords
Structural Basis of Polyketide Synthase O-Methylation.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00687
Abstract: Modular type I polyketide synthases (PKSs) produce some of the most chemically complex metabolites in nature through a series of multienzyme modules. Each module contains a variety of catalytic domains to selectively tailor the growing… read more here.
Keywords: polyketide; structural basis; basis polyketide; hydroxyl ... See more keywords
Depside Bond Formation by the Starter-Unit Acyltransferase Domain of a Fungal Polyketide Synthase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08585
Abstract: Depsides are polyphenolic molecules comprising two or more phenolic acid derivatives linked by an ester bond, which is called a depside bond in these molecules. Despite more than a century of intensive research on depsides,… read more here.
Keywords: polyketide synthase; bond formation; depside bond; starter unit ... See more keywords
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01344-3
Abstract: Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular chemical unit.… read more here.
Keywords: accelerated evolution; evolution; polyketide synthase; evolution modular ... See more keywords
Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70177-w
Abstract: Fungal polyketide synthase (PKS)–nonribosomal peptide synthetase (NRPS) hybrids are key enzymes for synthesizing structurally diverse hybrid natural products (NPs) with characteristic biological activities. Predicting their chemical space is of particular importance in the field of… read more here.
Keywords: space; peptide synthetase; analysis; chemical space ... See more keywords