Synthesis and Applications of Protein/Peptide‐Polymer Conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular Chemistry and Physics"
DOI: 10.1002/macp.201600595
Abstract: Recent advances in synthetic methodologies have brought us closer than ever to the precision conferred by nature. For example, the control possible in reversible deactivation radical polymerization enables us to design and synthesize macromolecules with… read more here.
Keywords: applications protein; polymer conjugates; peptide polymer; polymer ... See more keywords
One-Pot Synthesis of Thermoresponsive Amyloidogenic Peptide-Polymer Conjugates via Thio-Bromo "Click" Reaction of RAFT Polymers.
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201700507
Abstract: A synthetic strategy to efficiently prepare main-chain peptide-polymer conjugates probing their aggregation in solution is described. An in situ tandem reaction based on aminolysis/thio-bromo "click" reaction is performed to tether an amyloidogenic peptide fragment amyloid-β17-20… read more here.
Keywords: polymer conjugates; peptide polymer; polymer; reaction ... See more keywords
Intramolecular Interactions of Conjugated Polymers Mimic Molecular Chaperones to Stabilize Protein-Polymer Conjugates.
Sign Up to like & getrecommendations! Published in 2018 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b00927
Abstract: The power and elegance of protein-polymer conjugates has solved many vexing problems for society. Rational design of these complex covalent hybrids depends on a deep understanding of how polymer physicochemical properties impact the conjugate structure-function-dynamic… read more here.
Keywords: interactions conjugated; polymer conjugates; conjugated polymers; protein polymer ... See more keywords
Improved Ordering in Low Molecular Weight Protein-Polymer Conjugates Through Oligomerization of the Protein Block.
Sign Up to like & getrecommendations! Published in 2018 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b00928
Abstract: The self-assembly of protein-polymer conjugates incorporating oligomers of a small, engineered high-affinity binding protein, rcSso7d.SA, is studied to determine the effect of protein oligomerization on nanoscale ordering. Oligomerization enables a systematic increase in the protein… read more here.
Keywords: protein; block; polymer conjugates; oligomerization protein ... See more keywords
DNA-Polymer Conjugates by Photoinduced RAFT Polymerization.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01328
Abstract: Conventional grafting-to approaches to DNA-polymer conjugates are often limited by low reaction yields due to the sterically hindered coupling of a presynthesized polymer to DNA. The grafting-from strategy, in contrast, allows one to directly graft… read more here.
Keywords: polymer conjugates; dna; dna polymer; polymer ... See more keywords
Charge-Preserving Atom Transfer Radical Polymerization Initiator Rescues the Lost Function of Negatively Charged Protein-Polymer Conjugates.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b00379
Abstract: When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein-polymer conjugates can be applied to. More broadly speaking, independent of… read more here.
Keywords: negatively charged; charged protein; initiator; polymer conjugates ... See more keywords
Pyridyl Disulfide Reaction Chemistry: An Efficient Strategy toward Redox-Responsive Cyclic Peptide–Polymer Conjugates
Sign Up to like & getrecommendations! Published in 2019 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.9b00538
Abstract: Cyclic peptide–polymer conjugates are capable of self-assembling into supramolecular polymeric nanotubes driven by the strong multiple hydrogen bonding interactions between the cyclic peptides. In ... read more here.
Keywords: polymer conjugates; cyclic peptide; chemistry; pyridyl disulfide ... See more keywords
Nano-thin walled micro-compartments from transmembrane protein-polymer conjugates.
Sign Up to like & getrecommendations! Published in 2017 at "Soft matter"
DOI: 10.1039/c6sm02520j
Abstract: The high interfacial activity of protein-polymer conjugates has inspired their use as stabilizers for Pickering emulsions, resulting in many interesting applications such as synthesis of templated micro-compartments and protocells or vehicles for drug and gene… read more here.
Keywords: polymer conjugates; microscopy; protein polymer; micro compartments ... See more keywords
Pharmaceutical Functionalization of Monomeric Ionic Liquid for the Preparation of Ionic Graft Polymer Conjugates
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314731
Abstract: Polymerizable choline-based ionic liquid (IL), i.e., [2-(methacryloyloxy)ethyl]-trimethylammonium (TMAMA/Cl¯), was functionalized by an ion exchange reaction with pharmaceutical anions, i.e., cloxacillin (CLX¯) and fusidate (FUS¯), as the antibacterial agents. The modified biocompatible IL monomers (TMAMA/CLX¯, TMAMA/FUS¯)… read more here.
Keywords: ionic liquid; polymer conjugates; drug; graft ... See more keywords
Tumor Stimulus-Responsive Biodegradable Diblock Copolymer Conjugates as Efficient Anti-Cancer Nanomedicines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050698
Abstract: Biodegradable nanomedicines are widely studied as candidates for the effective treatment of various cancerous diseases. Here, we present the design, synthesis and evaluation of biodegradable polymer-based nanomedicines tailored for tumor-associated stimuli-sensitive drug release and polymer… read more here.
Keywords: diblock polymer; polymer; polymer conjugates; tumor ... See more keywords