Five-Year Outcomes of Biodegradable Polymer Drug-Eluting Stents Versus Second-Generation Durable Polymer Drug-Eluting Stents: a Meta-Analysis of Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-019-06912-x
Abstract: We investigated the safety and efficacy of biodegradable polymer drug-eluting stents (BP-DES) versus second-generation durable polymer drug-eluting stents (DP-DES) in a follow-up period of 5 years. A meta-analysis was performed using data from the PubMed,… read more here.
Keywords: eluting stents; drug eluting; polymer drug; second generation ... See more keywords
Impact of different coronary angioscopic findings on arterial healing one year after bioresorbable-polymer and second-generation durable-polymer drug-eluting stent implantation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cardiology"
DOI: 10.1016/j.jjcc.2020.03.016
Abstract: BACKGROUND The advantage of using bioresorbable-polymer drug-eluting stent (BP-DES) compared with second-generation durable-polymer drug-eluting stent (2G DP-DES) still remains controversial in clinical situations. The purpose of this study to evaluate the degree of re-endothelialization and… read more here.
Keywords: drug eluting; high grade; grade; ycp ... See more keywords
Molecularly imprinted polymer as drug delivery carrier in alginate dressing
Sign Up to like & getrecommendations! Published in 2017 at "Materials Letters"
DOI: 10.1016/j.matlet.2017.05.008
Abstract: Abstract Vancomycin was used as a template to obtain a molecularly imprinted polymer. The polymer imprinted with the antibiotic was encapsulated in alginate matrix to obtain a potential antibacterial wound dressing. The amount of vancomycin… read more here.
Keywords: alginate; drug delivery; imprinted polymer; polymer drug ... See more keywords
Phase behavior of the polymer/drug system PLA/DEET
Sign Up to like & getrecommendations! Published in 2017 at "Polymer"
DOI: 10.1016/j.polymer.2017.08.031
Abstract: Abstract The phase diagram of the binary polymer/drug system poly (lactic acid) (PLA) and N , N -diethyl-3-methylbenzamide (DEET) has been established for the purpose of screening the potential use of biocompatible and biodegradable PLA… read more here.
Keywords: drug system; phase; pla deet; polymer drug ... See more keywords
Instantaneous coprecipitation of polymer/drug microparticles using the supercritical assisted injection in a liquid antisolvent☆
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Supercritical Fluids"
DOI: 10.1016/j.supflu.2016.11.005
Abstract: Abstract In this work, the supercritical assisted injection in a liquid antisolvent (SAILA) has been proposed as a new technique to produce composite microparticles for drug controlled release. Coprecipitation has been attempted for different non-steroidal… read more here.
Keywords: drug; injection; polymer drug; liquid antisolvent ... See more keywords
COMPARISON OF LONG-TERM OUTCOMES WITH BIODEGRADABLE POLYMER DRUG ELUTING STENTS AND DURABLE POLYMER DRUG ELUTING STENTS: AN UPDATED META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)32087-8
Abstract: Long term outcomes of biodegradable polymer drug-eluting stents (BP-DES) compared to durable polymer drug-eluting stents (DP-DES), are not well described. A comprehensive search in clinicalTrials.gov, PubMed, EBSCO, Web of Science, google scholar and Ovid was… read more here.
Keywords: drug eluting; eluting stents; long term; term outcomes ... See more keywords
Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00239
Abstract: The reversible addition–fragmentation chain-transfer (RAFT) polymerization provides access to a broad variety of biocompatible and functional macromolecules for diverse polymer–drug conjugates. Due to thiocarbonylthio groups at the ends of each growing polymer chain, they can… read more here.
Keywords: polymer drug; raft; end; drug ... See more keywords
Insights into the Degradation of Polymer–Drug Conjugates by an Overexpressed Enzyme in Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01781
Abstract: Intensive efforts have been made to provide better treatments to cancer patients. Currently, nanoparticle-based drug delivery systems have gained propulsion, as they can overcome the drawbacks of free drugs. However, drug stability inside the nanocapsule… read more here.
Keywords: polymer drug; drug conjugates; mechanics; degradation ... See more keywords
Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00104
Abstract: During the dissolution of amorphous solid dispersions (ASDs), various phase transformations can occur, which will ultimately impact the degree of supersaturation. This study employed dissolution and diffusion measurements to compare the performance of various ASD… read more here.
Keywords: phase; drug; polymer drug; dissolution ... See more keywords
A modular and orthogonally reactive platform for fabrication of polymer–drug conjugates for targeted delivery
Sign Up to like & getrecommendations! Published in 2020 at "Polymer Chemistry"
DOI: 10.1039/d0py01049a
Abstract: Increasing interest in the utilization of polymeric systems in diagnostics and delivery has necessitated fabrication of polymers that can undergo facile functionalization with targeting groups and therapeutic/imaging agents in a modular and orthogonal fashion. Herein… read more here.
Keywords: drug conjugates; delivery; fabrication; drug ... See more keywords
Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2023.2167011
Abstract: Abstract Aim To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and E)-N-(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders. Methods The conjugates were characterised by 1HNMR, particle size analysis, SEM, LC-MS, TEM/EDX,… read more here.
Keywords: polymer drug; tacrine; drug conjugates; memantine tacrine ... See more keywords