Polymer-Lipid Hybrid Vesicles and Their Interaction with HepG2 Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.201906493
Abstract: Polymer-lipid hybrid vesicles are an emerging type of nano-assemblies that show potential as artificial organelles among others. Phospholipids and poly(cholesteryl methacrylate)-block-poly(methionine methacryloyloxyethyl ester (METMA)-random-2-carboxyethyl acrylate (CEA)) labeled with a Förster resonance energy transfer (FRET) reporter… read more here.
Keywords: hybrid vesicles; lipid hybrid; polymer lipid; hepg2 cells ... See more keywords
Polymer‐lipid hybrid nanoparticles: A novel drug delivery system for enhancing the activity of Psoralen against breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.03.006
Abstract: Graphical abstract Figure. No caption available. ABSTRACT A polymer‐lipid hybrid nanocarrier was developed to encapsulate psoralen (PSO) to improve its water solubility and bioavailability. The effects of PSO‐loaded polymer‐lipid hybrid nanoparticles (PSO‐PLNs) on breast cancer… read more here.
Keywords: breast; pso plns; lipid hybrid; polymer lipid ... See more keywords
Polymer Micelles vs Polymer–Lipid Hybrid Vesicles: A Comparison Using RAW 264.7 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01403
Abstract: Bottom-up synthetic biology aims to integrate artificial moieties with living cells and tissues. Here, two types of structural scaffolds for artificial organelles were compared in terms of their ability to interact with macrophage-like murine RAW… read more here.
Keywords: polymer lipid; lipid hybrid; 264 cells; micelles polymer ... See more keywords
Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b02917
Abstract: mRNA therapeutics hold great potential for treating a variety of diseases through protein-replacement, immunomodulation, and gene editing. However, much like siRNA therapy the majority of progress in mRNA delivery has been confined to the liver.… read more here.
Keywords: delivery; mrna; polymer lipid; lung endothelium ... See more keywords
Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c01368
Abstract: Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanoparticles that mimic functional components of host cell membranes, yielding… read more here.
Keywords: polymer lipid; polymer; virustatic polymer; entry ... See more keywords
Exploiting the Lymph Nodes-Amplifying Effect for Potent Systemic and Gastrointestinal Immune Responses via Polymer/Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b04071
Abstract: Parenteral vaccinations are not able to elicit effective systemic and gastrointestinal immune protection simultaneously since the lymphocytes are typically restricted to primed tissues. Although all-trans retinoic acid (atRA) was reported to trigger the gut-homing of… read more here.
Keywords: immune; systemic gastrointestinal; gastrointestinal immune; immune responses ... See more keywords
Development of topical Thymoquinone loaded polymer-lipid hybrid vesicular gel: in-vitro and ex-vivo evaluation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of liposome research"
DOI: 10.1080/08982104.2021.1929311
Abstract: Thymoquinone (TH), a naturally occurring moiety shows excellent anticancer properties and in the present study, TH loaded polymer hybrid lipid vesicles (TH PLH Vesicles) were formulated and in-vitro cytotoxicity towards breast cancer cell lines (MCF-7… read more here.
Keywords: vesicular gel; thymoquinone; lipid hybrid; polymer lipid ... See more keywords
Highlights on Cell-Penetrating Peptides and Polymer-Lipid Hybrid Nanoparticle: Overview and Therapeutic Applications for Targeted Anticancer Therapy
Sign Up to like & getrecommendations! Published in 2023 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-023-02576-x
Abstract: Polymer-lipid hybrid nanoparticles (PLHNs) have been widely used as a vehicle for carrying anticancer owing to its unique framework of polymer and lipid combining and giving the maximum advantages over the lipid and polymer nanoparticle… read more here.
Keywords: cell; polymer lipid; nanoparticle; lipid hybrid ... See more keywords
Surface Design Options in Polymer- and Lipid-Based siRNA Nanoparticles Using Antibodies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213929
Abstract: The mechanism of RNA interference (RNAi) could represent a breakthrough in the therapy of all diseases that arise from a gene defect or require the inhibition of a specific gene expression. In particular, small interfering… read more here.
Keywords: polymer lipid; surface design; design options; options polymer ... See more keywords
Enhanced oral bioavailability and gastroprotective effect of ibuprofen through mixed polymer-lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic delivery"
DOI: 10.4155/tde-2020-0125
Abstract: Objectives: The aim of this study was to design and formulate mixed polymer-lipid nanoparticles (PLNs) for the delivery of ibuprofen. Methods: The mixed PLNs were prepared by a single modified emulsification solvent evaporation method. Key… read more here.
Keywords: ibuprofen; bioavailability; mixed polymer; polymer lipid ... See more keywords