Polymer Modeling Predicts Chromosome Reorganization in Senescence
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DOI: 10.1016/j.celrep.2019.08.045
Abstract: Summary Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polymer simulations, microscopy, and mass spectrometry… read more here.
Keywords: chromosome reorganization; polymer modeling; senescence; reorganization senescence ... See more keywords
Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale
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DOI: 10.1080/19491034.2020.1868105
Abstract: ABSTRACT Interactions of chromatin with the nuclear lamina imposes a radial genome distribution important for nuclear functions. How physical properties of chromatin affect these interactions is unclear. We used polymer simulations to model how physical… read more here.
Keywords: physical constraints; polymer modeling; associations nuclear; chromatin associations ... See more keywords