Machine Learning on a Robotic Platform for the Design of Polymer–Protein Hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202201809
Abstract: Polymer–protein hybrids are intriguing materials that can bolster protein stability in non‐native environments, thereby enhancing their utility in diverse medicinal, commercial, and industrial applications. One stabilization strategy involves designing synthetic random copolymers with compositions attuned… read more here.
Keywords: polymer protein; protein hybrids; machine learning; design ... See more keywords
Design of a UCST Polymer with Strong Hydrogen Bonds and Reactive Moieties for Facile Polymer-Protein Hybridization.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01520
Abstract: Polymer-protein hybrids have been extensively used in biomedical fields. Polymers with upper critical solution temperature (UCST) behaviors can form a hydrated coacervate phase below the cloud point (Tcp), providing themselves the opportunity to directly capture… read more here.
Keywords: polymer protein; hydrogen bonds; polymer; ucst polymer ... See more keywords
Ligand-Binding Cooperativity Effects in Polymer-Protein Conjugation.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b00016
Abstract: We present an electron paramagnetic resonance (EPR) spectroscopic characterization of structural and dynamic effects that stem from post-translational modifications of bovine serum albumin (BSA), an established model system for polymer-protein conjugation. Beyond the typical drug… read more here.
Keywords: protein conjugation; polymer protein; spectroscopy; ligand binding ... See more keywords
Polymer–Protein Core–Shell Nanoparticles for Enhanced Antigen Immunogenicity
Sign Up to like & getrecommendations! Published in 2017 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.7b00049
Abstract: Nanoengineered vaccine platforms can be modeled after viruses and other pathogens with highly organized and repetitive structures that trigger the host immune system. Here we demonstrated a pyridine-grafted poly(e-caprolactone)-based polymer–protein core–shell nanoparticles (PPCS-NPs) platform can… read more here.
Keywords: protein core; core shell; polymer protein; shell nanoparticles ... See more keywords
Design and Application of Hybrid Polymer-Protein Systems in Cancer Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Polymers"
DOI: 10.3390/polym15092219
Abstract: Polymer-protein systems have excellent characteristics, such as non-toxic, non-irritating, good water solubility and biocompatibility, which makes them very appealing as cancer therapeutics agents. Inspiringly, they can achieve sustained release and targeted delivery of drugs, greatly… read more here.
Keywords: polymer protein; cancer therapy; protein systems; therapy ... See more keywords